Document Detail


A novel glycosignaling system: GQ1b-dependent neuritogenesis of human neuroblastoma cell line, GOTO, is closely associated with GQ1b-dependent ecto-type protein phosphorylation.
MedLine Citation:
PMID:  1303737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Previously, we reported that ganglioside GQ1b specifically promoted neuritogenesis of human neuroblastoma cells (GOTO), and also that is specifically stimulated the phosphorylation of several cell surface proteins on the same cells. To disclose the relationship between the two events, we examined them using a novel protein kinase inhibitor, K-252b, which is a derivative of K-252a and cannot pass through cell membrane. K-252b inhibited the GQ1b-dependent neuritogenesis as well as the GQ1b-stimulated phosphorylation. This suggests the direct coupling between the two cell events and the occurrence of a new biosignal transduction system.
Authors:
S Tsuji; T Yamashita; Y Matsuda; Y Nagai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurochemistry international     Volume:  21     ISSN:  0197-0186     ISO Abbreviation:  Neurochem. Int.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-06-29     Completed Date:  1993-06-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8006959     Medline TA:  Neurochem Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  549-54     Citation Subset:  IM    
Affiliation:
Frontier Research Program, RIKEN (The Institute of Physical and Chemical Research), Saitama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Carbazoles / pharmacology
Cell Membrane Permeability
Gangliosides / pharmacology*
Humans
Indole Alkaloids
Neurites / drug effects,  physiology*
Neuroblastoma / pathology*
Phosphoproteins / metabolism*
Phosphorylation
Protein Kinase Inhibitors
Signal Transduction / physiology*
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Carbazoles; 0/Gangliosides; 0/Indole Alkaloids; 0/Phosphoproteins; 0/Protein Kinase Inhibitors; 68652-37-9/GQ1b ganglioside; 97161-97-2/K 252

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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