| A novel glycosignaling system: GQ1b-dependent neuritogenesis of human neuroblastoma cell line, GOTO, is closely associated with GQ1b-dependent ecto-type protein phosphorylation. | |
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MedLine Citation:
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PMID: 1303737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previously, we reported that ganglioside GQ1b specifically promoted neuritogenesis of human neuroblastoma cells (GOTO), and also that is specifically stimulated the phosphorylation of several cell surface proteins on the same cells. To disclose the relationship between the two events, we examined them using a novel protein kinase inhibitor, K-252b, which is a derivative of K-252a and cannot pass through cell membrane. K-252b inhibited the GQ1b-dependent neuritogenesis as well as the GQ1b-stimulated phosphorylation. This suggests the direct coupling between the two cell events and the occurrence of a new biosignal transduction system. |
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Authors:
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S Tsuji; T Yamashita; Y Matsuda; Y Nagai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurochemistry international Volume: 21 ISSN: 0197-0186 ISO Abbreviation: Neurochem. Int. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-06-29 Completed Date: 1993-06-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006959 Medline TA: Neurochem Int Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 549-54 Citation Subset: IM |
Affiliation:
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Frontier Research Program, RIKEN (The Institute of Physical and Chemical Research), Saitama, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carbazoles
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pharmacology Cell Membrane Permeability Gangliosides / pharmacology* Humans Indole Alkaloids Neurites / drug effects, physiology* Neuroblastoma / pathology* Phosphoproteins / metabolism* Phosphorylation Protein Kinase Inhibitors Signal Transduction / physiology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Carbazoles; 0/Gangliosides; 0/Indole Alkaloids; 0/Phosphoproteins; 0/Protein Kinase Inhibitors; 68652-37-9/GQ1b ganglioside; 97161-97-2/K 252 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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