Document Detail


A novel ganglioside, 9-O-acetyl GD1b, is recognized by serum antibodies in Guillain-Barré syndrome.
MedLine Citation:
PMID:  8964919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A hitherto undescribed ganglioside was detected in a crude ganglioside fraction of bovine brain using an IgM M-protein binding to Gal beta 1, 3GalNAc residue. We purified and identified it as 9-O-acetyl GD1b based on results of alkali treatment that yielded GD1b and results of fast atom bombardment-mass and gas chromatography-mass spectrometries. 9-O-acetyl GD1b was also found to be present in human peripheral nerve tissue. The reactivities of the serum antibodies from patients with Guillain-Barré syndrome to 9-O-acetyl GD1b, GD1b, and GM1 were determined by ELISA and TLC immunostaining. Nineteen of 85 serum samples from Guillain-Barré syndrome patients had antibodies that bound to 9-O-acetyl GD1b: 14 of the positive samples also reacted with GM1 and GD1b, three reacted with GM1 but not with GD1b, one with GD1b but not with GM1, and one with neither GM1 nor GD1b. These results show that a subset of patients with Guillain-Barré syndrome had antibodies that react with 9-O-acetyl GD1b; therefore, this ganglioside can serve as a target antigen against the antibodies present in Guillain-Barré syndrome.
Authors:
S Hitoshi; S Kusunoki; K Kon; A Chiba; H Waki; S Ando; I Kanazawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  66     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-12-10     Completed Date:  1996-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  95-101     Citation Subset:  IM    
Affiliation:
Department of Neurology, Faculty of Medicine, University of Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies / immunology*
Cattle
Chromatography, Thin Layer
Enzyme-Linked Immunosorbent Assay
Gangliosides / immunology*
Gas Chromatography-Mass Spectrometry
Humans
Polyradiculoneuropathy / immunology*
Sciatic Nerve / immunology
Chemical
Reg. No./Substance:
0/9-O-acetyl-GD1b ganglioside; 0/Antibodies; 0/Gangliosides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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