Document Detail

[A novel function of tetrahydrobiopterin].
MedLine Citation:
PMID:  1361176     Owner:  NLM     Status:  MEDLINE    
6R-L-erythro-5, 6, 7, 8-Tetrahydrobiopterin (6R-BH4) is known as a cofactor for the hydroxylases of phenylalanine, tyrosine and tryptophan and also as a cofactor for nitric oxide synthase. Recently, a novel function of 6R-BH4 has been found: that is, 6R-BH4 acts on specific membrane receptors to directly stimulate the release of monamine neurotransmitters such as dopamine and serotonin, independently of its cofactor activity. In addition, it indirectly stimulates the release of non-monoamine neurotransmitters such as acetylcholine and glutamate, through activation of monoaminergic systems. In this paper, we briefly review recent experimental data, which provide new insights into the role of 6R-BH4 as a regulator of neuronal function. We also discuss the possibility of treatment by 6R-BH4 of neuropsychiatric diseases such as Parkinson's disease, Alzheimer's disease, depression and infantile autism.
S Miwa; Y Watanabe; K Koshimura; T Masaki
Publication Detail:
Type:  English Abstract; Journal Article; Review    
Journal Detail:
Title:  Nihon yakurigaku zasshi. Folia pharmacologica Japonica     Volume:  100     ISSN:  0015-5691     ISO Abbreviation:  Nippon Yakurigaku Zasshi     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-01-15     Completed Date:  1993-01-15     Revised Date:  2011-07-27    
Medline Journal Info:
Nlm Unique ID:  0420550     Medline TA:  Nihon Yakurigaku Zasshi     Country:  JAPAN    
Other Details:
Languages:  jpn     Pagination:  367-81     Citation Subset:  IM    
Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan.
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MeSH Terms
Alzheimer Disease / metabolism
Biopterin / analogs & derivatives*,  metabolism,  pharmacology,  physiology
Mixed Function Oxygenases
Neurotransmitter Agents / secretion*
Parkinson Disease / metabolism
Tissue Distribution
Reg. No./Substance:
0/Coenzymes; 0/Neurotransmitter Agents; 17528-72-2/5,6,7,8-tetrahydrobiopterin; 22150-76-1/Biopterin; EC 1.-/Mixed Function Oxygenases

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