| [A novel function of tetrahydrobiopterin]. | |
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MedLine Citation:
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PMID: 1361176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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6R-L-erythro-5, 6, 7, 8-Tetrahydrobiopterin (6R-BH4) is known as a cofactor for the hydroxylases of phenylalanine, tyrosine and tryptophan and also as a cofactor for nitric oxide synthase. Recently, a novel function of 6R-BH4 has been found: that is, 6R-BH4 acts on specific membrane receptors to directly stimulate the release of monamine neurotransmitters such as dopamine and serotonin, independently of its cofactor activity. In addition, it indirectly stimulates the release of non-monoamine neurotransmitters such as acetylcholine and glutamate, through activation of monoaminergic systems. In this paper, we briefly review recent experimental data, which provide new insights into the role of 6R-BH4 as a regulator of neuronal function. We also discuss the possibility of treatment by 6R-BH4 of neuropsychiatric diseases such as Parkinson's disease, Alzheimer's disease, depression and infantile autism. |
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Authors:
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S Miwa; Y Watanabe; K Koshimura; T Masaki |
Publication Detail:
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Type: English Abstract; Journal Article; Review |
Journal Detail:
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Title: Nihon yakurigaku zasshi. Folia pharmacologica Japonica Volume: 100 ISSN: 0015-5691 ISO Abbreviation: Nippon Yakurigaku Zasshi Publication Date: 1992 Nov |
Date Detail:
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Created Date: 1993-01-15 Completed Date: 1993-01-15 Revised Date: 2011-07-27 |
Medline Journal Info:
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Nlm Unique ID: 0420550 Medline TA: Nihon Yakurigaku Zasshi Country: JAPAN |
Other Details:
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Languages: jpn Pagination: 367-81 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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metabolism Animals Biopterin / analogs & derivatives*, metabolism, pharmacology, physiology Coenzymes Humans Mixed Function Oxygenases Neurotransmitter Agents / secretion* Parkinson Disease / metabolism Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Coenzymes; 0/Neurotransmitter Agents; 17528-72-2/5,6,7,8-tetrahydrobiopterin; 22150-76-1/Biopterin; EC 1.-/Mixed Function Oxygenases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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