Document Detail

A novel function of serum amyloid A: a potent stimulus for the release of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-8 by human blood neutrophil.
MedLine Citation:
PMID:  10679217     Owner:  NLM     Status:  MEDLINE    
High density lipoprotein (HDL) and its main apolipoproteins, AI and serum amyloid A (SAA), present in physiological and acute phase response conditions, respectively, affect the inflammatory process. This study focuses on the effect of AI, SAA, and HDL from healthy (N-HDL) and acute phase individuals (AP-HDL) on the release of TNF-alpha, IL-1beta, and IL-8 by human blood neutrophils. It was observed that SAA (100 microg/mL) causes a dramatic increase (75-400 times) in the basal liberation of the three cytokines assayed. This effect is not triggered by AP-HDL. Although AI (100 microg/ml) increases the release of IL-1beta and IL-8 modestly, N-HDL does not. Both HDLs (0.16-0.32 mg of protein/mL) had an anti-inflammatory action, decreasing the basal and LPS-stimulated cytokine release. Given that the biological role of SAA is still uncertain, the present study adds an important finding potentially pertinent to the biological role of this acute phase protein.
C J Furlaneto; A Campa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  268     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-03-10     Completed Date:  2000-03-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  405-8     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Academic Press.
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, CEP 05508-900, Brazil.
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MeSH Terms
Apolipoprotein A-I / metabolism
Cells, Cultured
Cytokines / metabolism*
Interleukin-1 / metabolism
Interleukin-8 / metabolism
Lipoproteins, HDL / metabolism
Neutrophils / metabolism*
Serum Amyloid A Protein / metabolism,  physiology*
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Cytokines; 0/Interleukin-1; 0/Interleukin-8; 0/Lipoproteins, HDL; 0/Serum Amyloid A Protein; 0/Tumor Necrosis Factor-alpha

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