| A novel function of serum amyloid A: a potent stimulus for the release of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-8 by human blood neutrophil. | |
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MedLine Citation:
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PMID: 10679217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High density lipoprotein (HDL) and its main apolipoproteins, AI and serum amyloid A (SAA), present in physiological and acute phase response conditions, respectively, affect the inflammatory process. This study focuses on the effect of AI, SAA, and HDL from healthy (N-HDL) and acute phase individuals (AP-HDL) on the release of TNF-alpha, IL-1beta, and IL-8 by human blood neutrophils. It was observed that SAA (100 microg/mL) causes a dramatic increase (75-400 times) in the basal liberation of the three cytokines assayed. This effect is not triggered by AP-HDL. Although AI (100 microg/ml) increases the release of IL-1beta and IL-8 modestly, N-HDL does not. Both HDLs (0.16-0.32 mg of protein/mL) had an anti-inflammatory action, decreasing the basal and LPS-stimulated cytokine release. Given that the biological role of SAA is still uncertain, the present study adds an important finding potentially pertinent to the biological role of this acute phase protein. |
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Authors:
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C J Furlaneto; A Campa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 268 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2000 Feb |
Date Detail:
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Created Date: 2000-03-10 Completed Date: 2000-03-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 405-8 Citation Subset: IM |
Copyright Information:
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Copyright 2000 Academic Press. |
Affiliation:
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Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, São Paulo, CEP 05508-900, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoprotein A-I
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metabolism Cells, Cultured Cytokines / metabolism* Humans Interleukin-1 / metabolism Interleukin-8 / metabolism Lipoproteins, HDL / metabolism Neutrophils / metabolism* Serum Amyloid A Protein / metabolism, physiology* Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Cytokines; 0/Interleukin-1; 0/Interleukin-8; 0/Lipoproteins, HDL; 0/Serum Amyloid A Protein; 0/Tumor Necrosis Factor-alpha |
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