Document Detail

A novel frequency domain fluorescence technique for determination of triplet decay times.
MedLine Citation:
PMID:  10368028     Owner:  NLM     Status:  MEDLINE    
Frequency domain fluorescence measurement using two diode lasers with amplitude modulation in the kHz range yields a signal component at the sum frequency. This intermodulation phenomenon was observed in an aqueous solution of haematoporphyrin (HP) and could be related to triplet state population kinetics. This indirect measurement technique may allow triplet decay time measurement during photodynamic therapy (PDT) enabling monitoring of the type II phototoxic damage rate.
H J Sterenborg; M E Janson; M J van Gemert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physics in medicine and biology     Volume:  44     ISSN:  0031-9155     ISO Abbreviation:  Phys Med Biol     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-08-20     Completed Date:  1999-08-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1419-26     Citation Subset:  IM    
Department of Radiotherapy, Daniel den Hoed Cancer Centre, University Hospital Rotterdam, The Netherlands.
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MeSH Terms
Biophysical Phenomena
Models, Theoretical
Neoplasms / drug therapy
Photochemotherapy* / statistics & numerical data
Reg. No./Substance:
0/Hematoporphyrins; 0/Solutions; 7732-18-5/Water

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