| A novel framework of circulatory equilibrium. | |
| | |
MedLine Citation:
|
PMID: 14764438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A novel framework of circulatory equilibrium was developed by extending Guyton's original concept. In this framework, venous return (CO(V)) for a given stressed volume (V) was characterized by a flat surface as a function of right atrial pressure (P(RA)) and left atrial pressure (P(LA)) as follows: CO(V) = V/W - G(S)P(RA) - G(P)P(LA), where W, G(S), and G(P) denote linear parameters. In seven dogs under total heart bypass, CO(V), P(RA), P(LA), and V were varied to determine the three parameters in each animal with use of multivariate analysis. The coefficient of determination (r(2) = 0.92-0.99) indicated the flatness of the venous return surface. The averaged surface was CO(V) = V/0.129 - 19.61P(RA) - 3.49P(LA). To examine the invariability of the surface parameters among animals, we predicted the circulatory equilibrium in response to changes in stressed volume in another 12 dogs under normal and heart failure conditions. This was achieved by equating the standard surface with the individually measured cardiac output (CO) curve. In this way, we could predict CO [y = 0.90x + 5.6, r(2) = 0.95, standard error of the estimate (SEE) = 8.7 ml.min(-1).kg(-1)], P(RA) (y = 0.96x, r(2) = 0.98, SEE = 0.2 mmHg), and P(LA) (y = 0.89x + 0.5, r(2) = 0.98, SEE = 0.8 mmHg) reasonably well. We conclude that the venous return surface accurately represents the venous return properties of the systemic and pulmonary circulations. The characteristics of the venous return surface are invariable enough among animals, making it possible to predict circulatory equilibrium, even if those characteristics are unknown in individual animals. |
| | |
Authors:
|
Kazunori Uemura; Masaru Sugimachi; Toru Kawada; Atsunori Kamiya; Yintie Jin; Koji Kashihara; Kenji Sunagawa |
Related Documents
:
|
9518718 - Human calf precapillary resistance decreases in response to small cumulative increases ... 1440498 - Tissue plasminogen activator release in chronic venous hypertension due to heart failure. 15636808 - Cardiac output measurements for guidance of perioperative intravenous hydration in an o... 684588 - Blood volume and hemodynamic changes in relation to extensive vascular operations. 12633698 - Partial left ventriculectomy in modified adriamycin-induced cardiomyopathy in the dog. 6797998 - Measurement of respiratory gas exchange during artificial respiration. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2004-02-05 |
Journal Detail:
|
Title: American journal of physiology. Heart and circulatory physiology Volume: 286 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2004 Jun |
Date Detail:
|
Created Date: 2004-05-18 Completed Date: 2004-06-28 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: H2376-85 Citation Subset: IM |
Affiliation:
|
Department of Cardiovascular Dynamics, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita 565-8565, Japan. kuemura@ri.ncvc.go.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Atrial Function, Right / physiology* Blood Pressure / physiology Cardiac Output / physiology* Dogs Male Models, Cardiovascular* Veins / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute hemodynamic responses in the head during microgravity induced by free drop in anesthetized rat...
Next Document: Transcription activator protein 1 mediates alpha- but not beta-adrenergic hypertrophic growth respon...