Document Detail

A novel family of growth factor receptors: a common binding domain in the growth hormone, prolactin, erythropoietin and IL-6 receptors, and the p75 IL-2 receptor beta-chain.
MedLine Citation:
PMID:  2554900     Owner:  NLM     Status:  MEDLINE    
Lymphokine and hematopoietic growth factors control the differentiation and proliferation of diverse cell types by binding to specific cell-surface receptors. Strikingly, the recently elucidated sequences of the interleukin-6 and erythropoietin receptors, and the interleukin-2 receptor beta-chain (p75), display a significant evolutionary resemblance of their extracellular domains. This homology extends to the binding domains of the growth hormone/prolactin class of receptors. Alternatively, little similarity exists between the cytoplasmic extensions of these diverse receptors. I discuss the evolutionary and functional implications of this broad, mosaic receptor relationship, with particular reference to possible structural resemblances between the cognate growth factors.
J F Bazan
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  164     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-12-11     Completed Date:  1989-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  788-95     Citation Subset:  IM    
Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448.
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MeSH Terms
Amino Acid Sequence
Erythropoietin / metabolism
Interleukin-6 / physiology
Macromolecular Substances
Molecular Sequence Data
Receptors, Cell Surface / genetics*
Receptors, Erythropoietin
Receptors, Immunologic / genetics*
Receptors, Interleukin-2 / genetics
Receptors, Interleukin-6
Receptors, Prolactin / genetics
Receptors, Somatotropin / genetics
Sequence Homology, Nucleic Acid
Reg. No./Substance:
0/Interleukin-6; 0/Macromolecular Substances; 0/Receptors, Cell Surface; 0/Receptors, Erythropoietin; 0/Receptors, Immunologic; 0/Receptors, Interleukin-2; 0/Receptors, Interleukin-6; 0/Receptors, Prolactin; 0/Receptors, Somatotropin; 11096-26-7/Erythropoietin

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