Document Detail

A novel experimental method to estimate stress-strain behavior of intact coronary arteries using intravascular ultrasound (IVUS).
MedLine Citation:
PMID:  12661205     Owner:  NLM     Status:  MEDLINE    
Most arterial mechanics studies have focused on excised non-coronary vessels, with few studies validating the application of ex-vivo results to in-vivo conditions. A method was developed for testing the mechanical properties of intact left anterior descending coronary arteries under a variety of conditions. Vascular deformation and pressure were simultaneously measured with intravascular ultrasound and a pressure transducer guidewire, respectively. Results suggest the importance of understanding in-vivo factors such as myocardial support, vascular tone and local pressure fluctuations when applying ex-vivo coronary characterization data. With further development, this method can more accurately characterize the true in-vivo constitutive behavior in normal and atherosclerotic coronaries.
Azita Tajaddini; Deborah L Kilpatrick; D Geoffrey Vince
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Validation Studies    
Journal Detail:
Title:  Journal of biomechanical engineering     Volume:  125     ISSN:  0148-0731     ISO Abbreviation:  J Biomech Eng     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-28     Completed Date:  2003-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909584     Medline TA:  J Biomech Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  120-3     Citation Subset:  IM    
Department of Biomedical Engineering/ND20 Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
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MeSH Terms
Arteries / physiopathology,  ultrasonography
Coronary Restenosis / physiopathology*,  ultrasonography*
Coronary Vessels / physiopathology*,  ultrasonography*
Feasibility Studies
Reproducibility of Results
Sensitivity and Specificity
Stress, Mechanical
Ultrasonography, Interventional / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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