Document Detail

A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenes.
MedLine Citation:
PMID:  9527769     Owner:  NLM     Status:  MEDLINE    
Erythromycin resistance among streptococci is commonly due to target site modification by an rRNA-methylating enzyme, which results in coresistance to macrolide, lincosamide, and streptogramin B antibiotics (MLSB resistance). Genes belonging to the ermAM (ermB) gene class are the only erythromycin resistance methylase (erm) genes in Streptococcus pyogenes with MLSB resistance that have been sequenced so far. We identified a novel erm gene, designated ermTR, from an erythromycin-resistant clinical strain of S. pyogenes (strain A200) with an inducible type of MLSB resistance. The nucleotide sequence of ermTR is 82.5% identical to ermA, previously found, for example, in Staphylococcus aureus and coagulase-negative staphylococci. Our finding provides the first sequence of an erm gene other than ermAM that mediates MLSB resistance in S. pyogenes.
H Seppälä; M Skurnik; H Soini; M C Roberts; P Huovinen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  42     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-31     Completed Date:  1998-03-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  257-62     Citation Subset:  IM    
Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland.
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MeSH Terms
Amino Acid Sequence
Anti-Bacterial Agents / pharmacology*
Bacterial Proteins / genetics*
Base Sequence
Drug Resistance, Microbial / genetics
Erythromycin / pharmacology*
Genes, Bacterial / genetics*
Methyltransferases / genetics*,  isolation & purification*
Microbial Sensitivity Tests
Molecular Sequence Data
Sequence Alignment
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Streptococcus pyogenes / drug effects,  enzymology,  genetics*
Grant Support
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bacterial Proteins; 114-07-8/Erythromycin; EC 2.1.1.-/ErmTR protein, bacteria; EC 2.1.1.-/Methyltransferases

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