| A novel erythromycin resistance methylase gene (ermTR) in Streptococcus pyogenes. | |
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MedLine Citation:
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PMID: 9527769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Erythromycin resistance among streptococci is commonly due to target site modification by an rRNA-methylating enzyme, which results in coresistance to macrolide, lincosamide, and streptogramin B antibiotics (MLSB resistance). Genes belonging to the ermAM (ermB) gene class are the only erythromycin resistance methylase (erm) genes in Streptococcus pyogenes with MLSB resistance that have been sequenced so far. We identified a novel erm gene, designated ermTR, from an erythromycin-resistant clinical strain of S. pyogenes (strain A200) with an inducible type of MLSB resistance. The nucleotide sequence of ermTR is 82.5% identical to ermA, previously found, for example, in Staphylococcus aureus and coagulase-negative staphylococci. Our finding provides the first sequence of an erm gene other than ermAM that mediates MLSB resistance in S. pyogenes. |
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Authors:
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H Seppälä; M Skurnik; H Soini; M C Roberts; P Huovinen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 42 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-03-31 Completed Date: 1998-03-31 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 257-62 Citation Subset: IM |
Affiliation:
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Antimicrobial Research Laboratory, National Public Health Institute, Turku, Finland. helena.seppala@utu.fi |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AF002716 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Anti-Bacterial Agents / pharmacology* Bacterial Proteins / genetics* Base Sequence Drug Resistance, Microbial / genetics Erythromycin / pharmacology* Genes, Bacterial / genetics* Methyltransferases / genetics*, isolation & purification* Microbial Sensitivity Tests Molecular Sequence Data Phenotype Phylogeny Sequence Alignment Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Streptococcus pyogenes / drug effects, enzymology, genetics* |
| Grant Support | |
ID/Acronym/Agency:
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DE 10913/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Bacterial Proteins; 114-07-8/Erythromycin; EC 2.1.1.-/ErmTR protein, bacteria; EC 2.1.1.-/Methyltransferases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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