Document Detail


A novel embolic stroke model resembling lacunar infarction following proximal middle cerebral artery occlusion in beagle dogs.
MedLine Citation:
PMID:  22722089     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It is estimated that lacunar infarcts account for 25% of all ischemic strokes, but its exact etiology is still on debating. The existing controversies include whether the embolisms can indeed cause lacunar stroke in humans or animal models. We hypothesized that lacunar infarction can be induced by the proximal middle cerebral artery (MCA) segmental occlusion involving the orifices of lenticulostriate arteries in animal models, which have abundant distal cerebral collateral anastomosis. Our work here establishes a proximal MCA occlusion model using thrombi (autologous blood clots about 1.7mm in diameter and 5mm in length) in 8 beagle dogs, evaluates the progression of ischemic lesions at 30minutes interval within 6hours after embolization using the diffusion weighted imaging (DWI), and discusses the potential mechanisms of lacunar infarction. Our results indicate that the left proximal MCAs can be successfully occluded in all dogs using interventional single-thrombus method. The small solitary or multiple ischemic lesions shown in DWI were observed in the deep brain area, with the mean detecting time of 1.21±0.45hours using DWI and diameter of 6.62±0.60mm in 6h-DWI after procedure. In conclusion, our method established an ischemic model which can recapitulate the radiologic and histologic changes in lacunar infarcts, suggesting that emboli can cause lacunar infarcts in animal model.
Authors:
Sheng Liu; Wei-Xing Hu; Qing-Quan Zu; Shan-Shan Lu; Xiao-Quan Xu; Lei Sun; Wei-Zhong Zhou; Hai-Bin Shi
Related Documents :
22084609 - Bihemispheric subcortical infarcts in the middle cerebral artery territory.
21726909 - Atrial fibrillation, arrhythmia burden and thrombogenesis.
1729059 - Utility of the peak expiratory flow rate in the differentiation of acute dyspnea. cardi...
19298559 - Potent antiarrhythmic effects of chronic amiodarone in canine pulmonary vein sleeve pre...
1517069 - Neurogenic pulmonary edema: a presenting symptom in multiple sclerosis.
8181359 - Prolonged treatment with almitrine for refractory hypoxemia in adult respiratory distre...
23041069 - Prognostic value of ct-evident cerebral infarcts in adult patients with tuberculous men...
22927019 - A case of late-onset sustained ventricular tachycardia following deployment of amplatze...
18651029 - Autophagy in the myocardium: dying for survival?
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-18
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  -     ISSN:  1872-678X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Screening of Elderly for Chronic Kidney Disease.
Next Document:  A modified and highly sensitive Golgi-Cox method to enable complete and stable impregnation of embry...