Document Detail

A novel dodecadepsipeptide, cereulide, is an emetic toxin of Bacillus cereus.
MedLine Citation:
PMID:  7781985     Owner:  NLM     Status:  MEDLINE    
A vacuole-formation substance, cereulide of Bacillus cereus, is an emetic toxin in animals. Both oral administration and intraperitoneal injection of cereulide caused dose-dependent emesis in Suncus murinus, a new animal model of emesis. Vagotomy or a 5-HT3 receptor antagonist completely abolished this emetic effect. Therefore, cereulide causes emesis through the 5-HT3 receptor and stimulation of the vagus afferent. We also found that our purified cereulide caused swelling of mitochondria of HEp-2 cells.
N Agata; M Ohta; M Mori; M Isobe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  FEMS microbiology letters     Volume:  129     ISSN:  0378-1097     ISO Abbreviation:  FEMS Microbiol. Lett.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-14     Completed Date:  1995-07-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7705721     Medline TA:  FEMS Microbiol Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  17-20     Citation Subset:  IM    
Nagoya City Public Health Research Institute, Japan.
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MeSH Terms
Bacillus cereus / pathogenicity*
Bacterial Toxins / toxicity*
Emetics / toxicity*
Peptides, Cyclic / toxicity*
Receptors, Serotonin / drug effects
Serotonin Antagonists / pharmacology
Reg. No./Substance:
0/Bacterial Toxins; 0/Depsipeptides; 0/Emetics; 0/Peptides, Cyclic; 0/Receptors, Serotonin; 0/Serotonin Antagonists; 0/cereulide

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