Document Detail


A novel copper(II) mononuclear complex with the non-steroidal anti-inflammatory drug diclofenac: Structural characterization and biological activity.
MedLine Citation:
PMID:  23280425     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A copper(II) complex with the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been for the first time synthesized and characterized without any co-organic ligand. Its biological activity against four human cell lines underlined a higher activity of the monomeric complex than the parent molecule in the case of tumoral cell lines. A ternary Cu-diclofenac-albumin complex was suspected to be the reactive species in biological medium.
Authors:
Stéphanie Sayen; Annie Carlier; Michel Tarpin; Emmanuel Guillon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-16
Journal Detail:
Title:  Journal of inorganic biochemistry     Volume:  120C     ISSN:  1873-3344     ISO Abbreviation:  J. Inorg. Biochem.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905788     Medline TA:  J Inorg Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  39-43     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Institut de Chimie Moléculaire de Reims (ICMR, UMR CNRS 7312), Groupe Chimie de Coordination, Université de Reims Champagne-Ardenne, F-51687 Reims Cedex 2, France.
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