| A novel centrifugal impeller bioreactor. II. Oxygen transfer and power consumption. | |
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MedLine Citation:
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PMID: 18629815 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The effects of the impeller configuration, aeration rate, and agitation speed on oxygen transfer coefficient K(L)a were studied in a newly designed centrifugal impeller bioreactor (5-L). The oxygen transfer rates in the novel bioreactor were also compared with those in a cell-lift bioreactor with comparable dimensions. The cell-lift impeller produced much higher surface oxygen transfer rates than the centrifugal one at an agitation speed over 200 rpm. This result was in good agreement with our observation that the cell-lift impeller produced much higher unfavorable turbulence. In addition, the experiments using granulated agar particles as pseudo plant cells indicated that the K(L)a value decreased steadily with an increase in agar particle concentration, and the centrifugal impeller still demonstrated a larger K(L)a than the cell lift up to a high pseudo cell concentration of 19.5 g dry weight (DW)/L (under 150 rpm and 0.20 vvm) or 22.3 g DW/L (under 200 rpm and 0.20 vvm). Furthermore, the correlation between power number and impeller Reynolds number for both the centrifugal and the cell-lift impellers was successfully obtained, which could be used for predicting the power input required by each impeller. From the results obtained, the centrifugal impeller bioreactor is expected to have great potential in its application to shear-sensitive biological systems. |
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Authors:
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S J Wang; J J Zhong |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biotechnology and bioengineering Volume: 51 ISSN: 0006-3592 ISO Abbreviation: Biotechnol. Bioeng. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 2008-07-16 Completed Date: 2009-12-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502021 Medline TA: Biotechnol Bioeng Country: United States |
Other Details:
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Languages: eng Pagination: 520-7 Citation Subset: - |
Affiliation:
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Biochemical Engineering Research Institute, East China University of Science and Technology, Shanghai 200237, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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