Document Detail


The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats.
MedLine Citation:
PMID:  17581535     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Drugs that interfere with cannabinoid CB1 transmission suppress various food-motivated behaviors, and it has been suggested that such drugs could be useful as appetite suppressants. Biochemical studies indicate that most of these drugs assessed thus far have been CB1 inverse agonists, and although they have been shown to suppress food intake, they also appear to induce nausea and malaise. The present studies were undertaken to characterize the behavioral effects of AM4113, which is a CB1 neutral antagonist, and to examine whether this drug can reduce food-reinforced behaviors and feeding on diets with varying macronutrient compositions. Biochemical data demonstrated that AM4113 binds to CB1 receptors, but does not show inverse agonist properties (ie no effects on cyclic-AMP production). In tests of spontaneous locomotion and analgesia, AM4113 reversed the effects of the CB1 agonist AM411. AM4113 suppressed food-reinforced operant responding with rats responding on fixed ratio (FR) 1 and 5 schedules of reinforcement in a dose-dependent manner, and also suppressed feeding on high-fat, high-carbohydrate, and lab chow diets. However, in the same dose range that suppressed feeding, AM4113 did not induce conditioned gaping, which is a sign of nausea and food-related malaise in rats. These results suggest that AM4113 may decrease appetite by blocking endogenous cannabinoid tone, and that this drug may be less associated with nausea than CB1 inverse agonists.
Authors:
Kelly S Sink; Peter J McLaughlin; Jodi Anne T Wood; Cara Brown; Pusheng Fan; V Kiran Vemuri; Yan Peng; Yan Pang; Teresa Olszewska; Teresa Olzewska; Ganesh A Thakur; Alex Makriyannis; Linda A Parker; John D Salamone
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-06-20
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  33     ISSN:  0893-133X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-12     Completed Date:  2008-07-03     Revised Date:  2013-09-04    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  946-55     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA.
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MeSH Terms
Descriptor/Qualifier:
Adamantane / analogs & derivatives,  pharmacology
Analysis of Variance
Animals
Behavior, Animal / drug effects
Conditioning, Operant / drug effects*
Cyclic AMP / metabolism
Dose-Response Relationship, Drug
Drug Interactions
Eating / drug effects*
Male
Motor Activity
Nausea / chemically induced*
Piperidines / pharmacology
Protein Binding / drug effects
Pyrazoles / pharmacology
Rats
Rats, Sprague-Dawley
Receptor, Cannabinoid, CB1 / agonists,  antagonists & inhibitors*
Reinforcement (Psychology)*
Tetrahydrocannabinol / analogs & derivatives,  pharmacology
Grant Support
ID/Acronym/Agency:
R01 DA007215/DA/NIDA NIH HHS; R37 DA023142/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/(-)-adamantyl-delta8-tetrahydrocannabinol; 0/AM 251; 0/AM4113; 0/Piperidines; 0/Pyrazoles; 0/Receptor, Cannabinoid, CB1; 1972-08-3/Tetrahydrocannabinol; 281-23-2/Adamantane; 60-92-4/Cyclic AMP
Comments/Corrections
Erratum In:
Neuropsychopharmacology. 2008 Jun;33(7):1776
Note: Pang, Yan [corrected to Peng, Yan]; Olzewska, Teresa [corrected to Olszewska, Teresa]

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