Document Detail


A novel brain-expressed protein related to carnitine palmitoyltransferase I.
MedLine Citation:
PMID:  12376098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Malonyl-CoenzymeA acts as a fuel sensor, being both an intermediate of fatty acid synthesis and an inhibitor of the two known isoforms of carnitine palmitoyltransferase I (CPT I), which control mitochondrial fatty acid oxidation. We describe here a novel CPT1 family member whose mRNA is present predominantly in brain and testis. Chromosomal locations and genome organization are reported for the mouse and human genes. The protein sequence contains all the residues known to be important for both carnitine acyltransferase activity and malonyl-CoA binding in other family members. Yeast expressed protein has no detectable catalytic activity with several different acyl-CoA esters that are good substrates for other carnitine acyltransferases, including the liver isoform of CPT I, which is also expressed in brain; however, it displays high-affinity malonyl-CoA binding. Thus this new CPT I related protein may be specialized for the metabolism of a distinct class of fatty acids involved in brain function.
Authors:
Nigel Price; Feike van der Leij; Vicky Jackson; Clark Corstorphine; Ross Thomson; Annette Sorensen; Victor Zammit
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genomics     Volume:  80     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-11     Completed Date:  2003-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  433-42     Citation Subset:  IM    
Affiliation:
Hannah Research Institute, Ayr, KA6 5HL, UK. pricen@hri.sari.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Brain / immunology,  metabolism*
Carnitine O-Palmitoyltransferase / biosynthesis,  genetics*,  immunology,  metabolism
Chromosome Mapping
Conserved Sequence
DNA, Complementary
Gene Expression Regulation
Humans
Introns
Mice
Molecular Sequence Data
Organ Specificity
Phylogeny
Sequence Alignment
Chemical
Reg. No./Substance:
0/DNA, Complementary; EC 2.3.1.21/Carnitine O-Palmitoyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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