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A novel biliary stent loaded with (125)I seeds in patients with malignant biliary obstruction: preliminary results versus a conventional biliary stent.
MedLine Citation:
PMID:  22266605     Owner:  NLM     Status:  Publisher    
BACKGROUND & AIMS: Stenting is a palliative therapy method for relieving malignant biliary obstruction. The aim was to evaluate the safety and effectiveness of a irradiation stent when compared to a conventional biliary stent in patients with biliary obstruction caused by both primary and metastatic adenocarcinomas. METHODS: Participants were randomly assigned to receive treatment with a biliary irradiation stent (irradiation stent group) or a conventional biliary stent (control group). After stent implantation, the outcomes were measured in terms of relief of obstructive jaundice, survival time, complications related to the procedure. A p-value of less than 0.05 was considered to indicate a significant difference. RESULTS: The stents were successfully placed in all 23 patients. The obstructive jaundice was relived in all patients except three in the control group. The median and mean overall survival in the irradiation stent group were longer than that in the control group (7.40 months vs. 2.50 months, 8.03 months vs. 3.36 months, p=0.006). The number of patients with stent patent at 3, 6, and 12 months in the irradiation stent group were 11(91.7%), 7(58.3%), and 1(8.3%), respectively. While in the control group, 4(36.4%), 1(9.1%), and 0(0%), respectively. There were no significant differences in the complications related to stent insertion between two groups. CONCLUSIONS: This interim analysis shows that treatment with the biliary intraluminal irradiation stent in patients with biliary obstruction caused by adenocarcinomas appears safe and technical feasible and has benefits in relieving jaundice, and seems to extend survival when compared to a conventional biliary stent.
Hai-Dong Zhu; Jin-He Guo; Guang-Yu Zhu; Shi-Cheng He; Wen Fang; Gang Deng; Yong-Lin Qin; Guo-Zhao Li; Douglas M Coldwell; Gao-Jun Teng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-17
Journal Detail:
Title:  Journal of hepatology     Volume:  -     ISSN:  0168-8278     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Department of Radiology, Zhong-Da Hospital, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China.
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