| A novel balloon angioplasty catheter impregnated with beta-particle emitting radioisotopes for vascular brachytherapy to prevent restenosis; first in vivo results. | |
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MedLine Citation:
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PMID: 11102256 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: According to early clinical trials, vascular brachytherapy performed prior to or shortly after angioplasty is very effective in reducing restenosis rates. The purpose of this study was to investigate the effects of a novel radioactive catheter that allows simultaneous balloon angioplasty and beta-particle irradiation in the prevention of restenosis. MATERIAL AND METHODS: The balloon surface of an angioplasty catheter was impregnated with the radioisotope(32)P. Dosimetry calculations using a Monte Carlo method were performed at a radial distance of 0.2 mm from the balloon surface. Rabbit iliac arteries were dilated and simultaneously irradiated with a dose of 20 Gy delivered to the adventitia. Control arteries were only dilated and not irradiated. Neointimal areas, cell numbers and the perimeter of the arteries were measured by histomorphometry after 6 weeks. RESULTS: Neointima formation was reduced after balloon dilatation and simultaneous beta-particle irradiation using the(32)P impregnated angioplasty catheter as compared to balloon dilatation alone with a non-impregnated catheter (0.09+/-0.06 vs 0.27+/-0.09 mm(2)neointimal area and 168+/-45 vs 360+/-133 cells/0.05 mm(2)neointima, P<0.001 vs control, respectively). In addition, balloon dilatation with the(32)P impregnated angioplasty catheter increased the vessel perimeter as compared to balloon dilatation with a non-impregnated catheter (4. 7+/-0.2 vs 3.9+/-0.3 mm, P<0.001 vs control). CONCLUSIONS: Simultaneous balloon dilatation and vascular brachytherapy with a novel(32)P impregnated angioplasty catheter markedly reduces restenosis in vivo by preventing neointimal hyperplasia and constrictive vascular remodelling. |
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Authors:
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C Hehrlein; A Kovacs; G K Wolf; N Yue; R Nath |
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Publication Detail:
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Type: Evaluation Studies; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European heart journal Volume: 21 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-30 Completed Date: 2001-02-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2056-62 Citation Subset: IM |
Copyright Information:
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Copyright 2000 The European Society of Cardiology. |
Affiliation:
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Department of Cardiology, University of Freiburg and Heidelburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Balloon* Animals Arteriosclerosis / radiotherapy* Beta Particles Brachytherapy* / methods Catheterization Female Hyperplasia Iliac Artery Models, Animal Monte Carlo Method Phosphorus Radioisotopes / administration & dosage Rabbits Radiotherapy Dosage Recurrence Tunica Intima / pathology, radiation effects |
| Grant Support | |
ID/Acronym/Agency:
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1-RO1-HL58022-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Phosphorus Radioisotopes |
| Comments/Corrections | |
Comment In:
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Eur Heart J. 2000 Dec;21(24):1994-6
[PMID:
11102248
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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