| A novel approach to paraneoplastic intestinal pseudo-obstruction. | |
| | |
MedLine Citation:
|
PMID: 22072051 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Paraneoplastic neurologic syndromes (PNS) are uncommon, affecting fewer than 1 in 10,000 patients with cancer. PNS, while rare, can cause significant morbidity and impose enormous socio-economic costs, besides severely affecting quality of life. PNS can involve any part of the nervous system and can present as limbic encephalitis, subacute cerebellar ataxias, opsoclonus-myoclonus, retinopathies, chronic intestinal pseudo-obstruction (CIPO), sensory neuronopathy, Lambert-Eaton myasthenic syndrome, stiff-person syndrome, and encephalomyelitis. The standard of care for CIPO includes the use of promotility and anti-secretory agents and the resection of the non-functioning gut segment; all of which can cause significant compromise in the quality of life. There is significant evidence that paraneoplastic neurologic syndromes are associated with antibodies directed against certain nerve antigens. We successfully treated a patient with CIPO in the setting of small cell lung cancer with a combination of rituximab and cyclophosphamide. The patient, who had failed to respond to prokinetic agents, anti-secretory therapy, and multiple resections, responded to the immunomodulatory therapy, with minimal residuals with PEG tube feeding and sustained ostomy output. The use of rituximab and cyclophosphamide should therefore be considered in patients with CIPO, especially if it can avoid complicated surgical procedures. |
| | |
Authors:
|
Ambuga Badari; Deborah Farolino; Eiad Nasser; Shahid Mehboob; David Crossland |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-10 |
Journal Detail:
|
Title: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer Volume: - ISSN: 1433-7339 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9302957 Medline TA: Support Care Cancer Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
University at Buffalo, Buffalo, NY, USA, badariar@gmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thyroid cancer patients' involvement in adjuvant radioactive iodine treatment decision-making and de...
Next Document: Sterically Stabilized Liposomes Incorporating the Novel Anticancer Agent Phospho-Ibuprofen (MDC-917)...