Document Detail

A novel approach to chronic total occlusions: the crosser system.
MedLine Citation:
PMID:  16764006     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To evaluate safety and efficacy of the CROSSER CTO Recanalization System (CROSSER). BACKGROUND: The CROSSER, a novel device dedicated to recanalization of chronic total occlusions (CTO), relies on a monorail catheter delivering vibrational energy to facilitate the crossing of occluded coronary arteries. METHODS: We included de novo or restenotic occlusions in native coronary arteries with typically unfavorable characteristics and a prior failed guidewire attempt either performed in a previous procedure or just before the usage of the CROSSER. The end points analyzed were technical success (ability to cross or facilitate a guidewire crossing into the true lumen), angiographic success (<20% residual stenosis and TIMI flow grade 3), and clinical success (angiographic success and freedom from major adverse cardiac events at 30 days). RESULTS: Twenty-eight patients (30 lesions) were included. The morphology was blunt in 83.3% and the length of the occlusion was >20 mm in 76.6%. The median age of the CTO was 9 months (range 3-60 months). Technical success was obtained in 19 (63%) occlusions and angiographic success in 16 (53%): 26.3% in lesions with prior procedural failure and 73.7% when CROSSER was attempted after initial guidewire failure. Complications were: one guidewire perforation without consequences and one peri-procedural myocardial infarction (MI). No events occurred within 30-day follow-up after discharge. CONCLUSIONS: In our experience, the CROSSER System is safe and increases the success of opening CTO refractory to guidewires. This novel device may represent an useful adjunct to the armamentarium of the interventional cardiologist.
Gloria Melzi; John Cosgrave; Giuseppe L Biondi-Zoccai; Flavio Airoldi; Iassen Michev; Alaide Chieffo; Giuseppe M Sangiorgi; Matteo Montorfano; Mauro Carlino; Antonio Colombo
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  68     ISSN:  1522-1946     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-28     Completed Date:  2006-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
Copyright Information:
Copyright 2006 Wiley-Liss, Inc.
EMO Centro Cuore Columbus, Milan, Italy.
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MeSH Terms
Chronic Disease
Coronary Angiography
Coronary Circulation
Coronary Disease / physiopathology,  radiography,  therapy*
Equipment Design
Heart Catheterization / instrumentation*
Middle Aged
Treatment Outcome
Vibration / therapeutic use*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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