Document Detail

A novel application of plasma and cerebrospinal fluid level of epstein barr virus DNA in the diagnosis of leptomeningeal metastasis from nasopharyngeal carcinoma. A case report.
MedLine Citation:
PMID:  18547967     Owner:  NLM     Status:  MEDLINE    
Epstein Barr virus (EBV)-associated nasopharyngeal carcinoma (NPC) is endemic in Southeast Asia, and the plasma level of EBV DNA is a highly sensitive marker of disease recurrence following radiotherapy. Leptomeningeal recurrence from NPC is extremely rare and difficult to diagnose; only 4 cases have been reported in the literature. We report a case of leptomeningeal recurrence in NPC that was diagnosed using imaging and plasma and cerebrospinal fluid EBV DNA assays, followed by a review of the literature.
Ada T W Ma; Brigette B Y Ma; Peter M L Teo; Anthony T C Chan
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2008-06-12
Journal Detail:
Title:  Oncology     Volume:  74     ISSN:  1423-0232     ISO Abbreviation:  Oncology     Publication Date:  2008  
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0135054     Medline TA:  Oncology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  119-22     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China.
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MeSH Terms
DNA, Viral / blood*,  cerebrospinal fluid*
Herpesvirus 4, Human / genetics*
Meningeal Neoplasms / diagnosis,  secondary*,  virology*
Nasopharyngeal Neoplasms / pathology*,  virology*
Reg. No./Substance:
0/DNA, Viral

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