| A novel appetite peptide, nesfatin-1 in patients with non-alcoholic fatty liver disease. | |
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MedLine Citation:
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PMID: 22950627 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background and aims. Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver pathology worldwide and is strongly associated with obesity and insulin-resistance and food intake. Nesfatin-1 is a new peptide that controls appetite and food intake. The objective of this research was to examine the serum concentrations of nesfatin-1 in NAFLD. Material and methods. Thirty NAFLD patients who had elevated liver enzymes and 40 age- and sex-matched healthy subjects were included in this study. NAFLD was diagnosed and graded with the findings of liver ultrasound scan. Nesfatin-1 concentrations were measured using an ELISA method and the relationship between nesfatin-1 and metabolic parameters were investigated. The subjects were divided into two groups according to their body mass index (≥ 30 and < 30) and nesfatin-1 concentrations were examined between both groups. Results. Serum nesfatin-1 concentrations in NAFLD patients were lower than healthy controls (0.26 ± 0.14 ng/ml, 0.38 ± 0.18 ng/ml, respectively, and p = 0.008). We found a negative correlation between nesfatin-1 and fasting glucose and body mass index. In obese subjects, serum nesfatin-1 concentrations were significantly lower when compared with non-obese subjects (0.26 ± 0.12 ng/ml, 0.37 ± 0.19 ng/ml, respectively; p = 0.014). In addition, we showed that nesfatin-1 concentrations in subjects with insulin resistance were significantly lower in comparison with insulin-sensitive ones (0.27 ± 0.17 ng/ml, 0.38 ± 0.17 ng/ml, respectively; p = 0.015). Conclusion. Our study has shown that nesfatin-1 concentrations were reduced in NAFLD. The results of this study indicate that nesfatin-1 may have a significant role in NAFLD. |
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Authors:
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Omer Başar; Erdem Akbal; Seyfettin Köklü; Erdem Koçak; Yaşar Tuna; Fuat Ekiz; Selcan Gültuna; Fatma Meriç Yιlmaz; Temuçin Aydoğan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-5 |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: - ISSN: 1502-7686 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Gastroenterology, Dιşkapι Yιldιrιm Beyazιt Educational and Research Hospital , Ankara , Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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