Document Detail


A novel apparatus that permits multiple routes for infusions and body-fluid collections in a freely-moving animal.
MedLine Citation:
PMID:  7609577     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel apparatus is described for simultaneous performance of multi-channel infusions/body-fluid collections and multichannel electrical recordings/stimulations in a freely behaving animals. This apparatus consists of a cylindrical cage and other devices described below. Electrical contacts are achieved via a slip-ring commutator. A rotation detector detects the turning of the animal in the cage, and a controller rotates the floor under the animal in the opposite direction by means of a stepping motor. Thus, excessive twisting of the fluid tubing between the animal and experimental equipment is released by rotation of the floor. Floor rotation starts when the animal turns in either direction and exceeds a present number of rotations. When the turning exceeds certain rates, the floor is rotated with higher angular velocities. This floor rotation little affected sleep-wake activities, brain temperature, food and water intake, and general behavior of the rat. Thus, multi-channel fluid routes have been realized; and by excluding the swivel apparatus from the fluid lines, advantages such as no fluid leakage at the swivel, no extra dead volume, and low torque to rotate the device have been gained.
Authors:
H Matsumura; G Kinoshita; S Satoh; T Osaka; O Hayaishi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroscience methods     Volume:  57     ISSN:  0165-0270     ISO Abbreviation:  J. Neurosci. Methods     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-15     Completed Date:  1995-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905558     Medline TA:  J Neurosci Methods     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  145-9     Citation Subset:  IM    
Affiliation:
Osaka Bioscience Institute, Suita, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Fluids*
Brain / physiology
Drinking
Eating
Electric Stimulation
Electromyography
Housing, Animal
Microdialysis
Monitoring, Physiologic / instrumentation
Motor Activity / physiology*
Perfusion* / instrumentation
Rats
Rats, Sprague-Dawley
Sleep
Specimen Handling* / instrumentation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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