| A novel antioestrogen agent (3R,6R)-bassiatin inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression in 17β-oestradiol-treated MCF-7 cells. | |
| | |
MedLine Citation:
|
PMID: 21241249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bassiatin [(3R,6R)-bassiatin] was isolated from the endogenous fungus Fusarium oxysporum J8-1-2. We found that oestrogen-dependent cell growth was inhibited by bassiatin in MCF-7 ERα (oestrogen receptor α)-positive breast cancer cells. In addition, the mRNA and protein levels of ERα and the oestrogen-responsive gene cyclin D1 were down-regulated by bassiatin in the presence of 17β-oestradiol. Co-treatment of 17β-oestradiol and bassiatin increased phospho-cyclin D1 (Thr286), an indicator of cyclin D1 phosphorylation-dependent degradation. However, this effect was not obvious in the absence of 17β-oestradiol, suggesting that bassiatin may play a role in the metabolism of cyclin D1 by decreasing cyclin D1 protein expression in the presence of 17β-oestradiol. Cyclin D1, known as a key cell cycle regulator, regulates the transition of G1- and S-phase. Decreased cyclin D1 was found to be involved in bassiatin-induced MCF-7 cell cycle arrest. Collectively, our study showed that bassiatin induced cell cycle arrest and exerted an antioestrogen effect. It may prove to be a potential drug target for antioestrogen therapy in ERα-positive breast cancer. |
| | |
Authors:
|
Li Meng; Bo Feng; Hongwen Tao; Tingting Yang; Yan Meng; Weiming Zhu; Caiguo Huang |
Related Documents
:
|
3962679 - Rheumatoid pleurisy. specificity of cytological findings. 4234789 - Atypical cells in the peripheral blood of chickens exposed to marek's disease agent. 16783769 - Direct intrauterine sampling with uterobrush: cell preparation by the "flicked" method. 21518959 - A klf4-mirna-206 autoregulatory feedback loop can promote or inhibit protein translatio... 22553519 - Effects of endothelin-1 on the cytoskeleton protein f-actin of human trabecular meshwor... 9181319 - Malignant pleural effusions due to adeno-endocrine-cell carcinoma of the appendix: a ca... 7189319 - Formation of large vacuoles in tumour cells grown in suspension. 3346329 - The effects of heat shock on the morphology and protein synthesis of the epidermis of x... 21641729 - Ovarian enzymatically active stromal cells can be a promoter of ovarian surface epithel... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cell biology international Volume: 35 ISSN: 1095-8355 ISO Abbreviation: Cell Biol. Int. Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-05-12 Completed Date: 2011-09-02 Revised Date: 2012-08-02 |
Medline Journal Info:
|
Nlm Unique ID: 9307129 Medline TA: Cell Biol Int Country: England |
Other Details:
|
Languages: eng Pagination: 599-605 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry and Molecular Biology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, Peoples Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Line, Tumor Cell Proliferation / drug effects Cyclin D1 / genetics, metabolism* Down-Regulation Estradiol / pharmacology* Estrogen Receptor Modulators / chemistry, pharmacology* Estrogen Receptor alpha / chemistry, genetics, metabolism* Fusarium / chemistry G1 Phase / drug effects Humans Morpholines / chemistry, pharmacology* Phosphorylation S Phase / drug effects Stereoisomerism |
| Chemical | |
Reg. No./Substance:
|
0/Estrogen Receptor Modulators; 0/Estrogen Receptor alpha; 0/Morpholines; 136601-57-5/Cyclin D1; 50-28-2/Estradiol; 65454-13-9/lateritin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vitro investigation of renal epithelial injury suggests that primary cilium length is regulated b...
Next Document: Effect of cobalt-60 (? radiation) on multidrug-resistant multiple myeloma cell lines.