| A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats. | |
| | |
MedLine Citation:
|
PMID: 22293188 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Nesfatin-1 is a novel adipocytokine which exerts not only anorexigenic but also hypertensive roles through acting on hypothalamus melanocortin-3/4 receptors. Although it is logical to hypothesize that nesfatin-1 could also affect the contractile reactivity of peripheral blood vessels, it still remains to be examined. The present study was performed to test the hypothesis. In both endothelium-intact and -denuded mesenteric artery of rats, acute treatment with nesfatin-1 (10nM, 30min pretreatment) had no influence on the noradrenaline- and 5-hydroxytryptamine-induced concentration-dependent contractions. Chronic treatment of mesenteric artery with nesfatin-1 (10nM, 3days) using organ-culture method had also no influence on the agonists-induced contractions. In contrast, nesfatin-1 (10nM, 30min) significantly inhibited the sodium nitroprusside (SNP)-induced relaxations of smooth muscle in mesenteric artery. A membrane permeable cyclic GMP (cGMP) analog, 8-bromo-cGMP-induced relaxations were not affected by nesfatin-1. Consistently, the SNP-induced cGMP production in smooth muscle was impaired by nesfatin-1. Intravenous application of nesfatin-1 to rats not only increased blood pressure but also impaired the SNP-induced decreases in blood pressure. The present study for the first time reveals that nesfatin-1 affects peripheral arterial blood vessel and inhibits the nitric oxide donor-induced smooth muscle relaxations via impairing the cGMP production. The results are the first to demonstrate that nesfatin-1 modulates blood pressure through directly acting on peripheral arterial resistance. |
| | |
Authors:
|
Hideyuki Yamawaki; Minako Takahashi; Masashi Mukohda; Tomoka Morita; Muneyoshi Okada; Yukio Hara |
Related Documents
:
|
22327038 - Doxycycline ameliorates 2k-1c hypertension-induced vascular dysfunction in rats by atte... 20156728 - Effects of body position on the ventilatory response to hypercapnia. 3526888 - Hemodynamic effects of positive end-expiratory pressure. historical perspective. 3996788 - Body position and acoustic admittance. 20185658 - The ability of pleth variability index to predict the hemodynamic effects of positive e... 8562468 - Vascular protective effects of ace inhibitors and calcium antagonists: theoretical basi... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
|
Title: Biochemical and biophysical research communications Volume: - ISSN: 1090-2104 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012. Published by Elsevier Inc. |
Affiliation:
|
Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Actions of a novel water-soluble benzodiazepine-receptor agonist JM 1232(-) on synaptic transmission...
Next Document: Upregulation of thromboxane synthase mediates visfatin-induced interleukin-8 expression and angiogen...