Document Detail

A novel adipocytokine, nesfatin-1 modulates peripheral arterial contractility and blood pressure in rats.
MedLine Citation:
PMID:  22293188     Owner:  NLM     Status:  MEDLINE    
Nesfatin-1 is a novel adipocytokine which exerts not only anorexigenic but also hypertensive roles through acting on hypothalamus melanocortin-3/4 receptors. Although it is logical to hypothesize that nesfatin-1 could also affect the contractile reactivity of peripheral blood vessels, it still remains to be examined. The present study was performed to test the hypothesis. In both endothelium-intact and -denuded mesenteric artery of rats, acute treatment with nesfatin-1 (10nM, 30min pretreatment) had no influence on the noradrenaline- and 5-hydroxytryptamine-induced concentration-dependent contractions. Chronic treatment of mesenteric artery with nesfatin-1 (10nM, 3days) using organ-culture method had also no influence on the agonists-induced contractions. In contrast, nesfatin-1 (10nM, 30min) significantly inhibited the sodium nitroprusside (SNP)-induced relaxations of smooth muscle in mesenteric artery. A membrane permeable cyclic GMP (cGMP) analog, 8-bromo-cGMP-induced relaxations were not affected by nesfatin-1. Consistently, the SNP-induced cGMP production in smooth muscle was impaired by nesfatin-1. Intravenous application of nesfatin-1 to rats not only increased blood pressure but also impaired the SNP-induced decreases in blood pressure. The present study for the first time reveals that nesfatin-1 affects peripheral arterial blood vessel and inhibits the nitric oxide donor-induced smooth muscle relaxations via impairing the cGMP production. The results are the first to demonstrate that nesfatin-1 modulates blood pressure through directly acting on peripheral arterial resistance.
Hideyuki Yamawaki; Minako Takahashi; Masashi Mukohda; Tomoka Morita; Muneyoshi Okada; Yukio Hara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-01-24
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  418     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-02-27     Completed Date:  2012-04-16     Revised Date:  2012-10-25    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  676-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Kitasato University, Aomori 034-8628, Japan.
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MeSH Terms
Adipokines / pharmacology,  physiology*
Antihypertensive Agents / pharmacology
Blood Pressure / drug effects,  physiology*
Calcium-Binding Proteins / pharmacology,  physiology*
Cyclic GMP / metabolism
DNA-Binding Proteins / pharmacology,  physiology*
Hypothalamus / physiology
Mesenteric Arteries / drug effects,  physiology
Muscle Contraction / drug effects,  physiology*
Muscle, Smooth / drug effects,  physiology
Nerve Tissue Proteins / pharmacology,  physiology*
Nitroprusside / pharmacology
Organ Culture Techniques
Rats, Wistar
Vascular Resistance / drug effects,  physiology*
Vasoconstriction / drug effects,  physiology*
Vasodilation / drug effects,  physiology*
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Adipokines; 0/Antihypertensive Agents; 0/Calcium-Binding Proteins; 0/DNA-Binding Proteins; 0/Nerve Tissue Proteins; 0/Vasodilator Agents; 0/nucleobindin; 15078-28-1/Nitroprusside; 7665-99-8/Cyclic GMP

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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