Document Detail

A novel SCFA receptor, the microbiota, and blood pressure regulation.
MedLine Citation:
PMID:  24429443     Owner:  NLM     Status:  Publisher    
The maintenance of blood pressure homeostasis is a complex process which is carefully regulated by a variety of inputs. We recently identified two sensory receptors (Olfactory receptor 78 and G protein couple receptor 41) as novel regulators of blood pressure. Both Olfr78 and Gpr41 are receptors for short chain fatty acids (SCFAs), and we showed that propionate (a SCFA) modifies blood pressure in a manner which is differentially modulated by the absence of either Olfr78 or Gpr41. In addition, propionate modifies renin release in an Olfr78-dependent manner. Our study also demonstrated that antibiotic treatment modulates blood pressure in Olfr78 null mice, indicating that SCFAs produced by the gut microbiota likely influence blood pressure regulation. In this addendum, we summarize the findings of our recent study and provide a perspective on the implications of the interactions between the gut microbiota and blood pressure control.
Jennifer Pluznick
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-12-20
Journal Detail:
Title:  Gut microbes     Volume:  5     ISSN:  1949-0984     ISO Abbreviation:  Gut Microbes     Publication Date:  2013 Dec 
Date Detail:
Created Date:  2014-1-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101495343     Medline TA:  Gut Microbes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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