| A novel MRI-biomarker candidate for Alzheimer's disease composed of regional brain volume and perfusion variables. | |
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MedLine Citation:
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PMID: 20443979 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Earlier evidence indicates that regional cerebral volume (rVOL) and blood flow (rCBF) variables carry independent information on incipient and early Alzheimer's disease (AD) and combining these modalities may increase discriminant performance. We compared single variables and combinations regarding their power for optimizing diagnostic accuracy. METHODS: Twelve cognitively normal elderly controls (CN), 30 subjects with mild cognitive impairment (MCI) and 15 with mild AD were examined by structural and perfusion-weighted magnetic resonance imaging (MRI) in single sessions at 1.5 Tesla. rVOLs were measured by manual volumetry, and rCBFs were calculated with a ROI-based co-localization technique. RESULTS: Applying single MRI variables for the differentiation of AD versus CN, the area under curve (AUC) of receiver operating characteristic curves (ROCCs) was highest for rVOL variables (maximum of 0.972 for right amygdala). A composite marker selected and weighted by logistic regression containing left amygdalar rCBF, left hippocampal and right amygdalar rVOLs gave a diagnostic accuracy for AD versus CN of 100%. Internal cross-validation revealed a reliability of 88.9%. CONCLUSIONS: Whilst external revalidation is mandatory employing a naturalistic sample containing disease controls, our phase I/II findings demonstrate that deducing composite markers from multimodal MRI acquisitions can optimize diagnostic accuracy for AD. |
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Authors:
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C Luckhaus; M Jänner; M Cohnen; M O Flüss; S J Teipel; M Grothe; H Hampel; J Kornhuber; E Rüther; O Peters; T Supprian; W Gaebel; U Mödder; H-J Wittsack |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of neurology : the official journal of the European Federation of Neurological Societies Volume: 17 ISSN: 1468-1331 ISO Abbreviation: Eur. J. Neurol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506311 Medline TA: Eur J Neurol Country: England |
Other Details:
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Languages: eng Pagination: 1437-44 Citation Subset: IM |
Copyright Information:
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© 2010 The Author(s). European Journal of Neurology © 2010 EFNS. |
Affiliation:
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Department of Psychiatry and Psychotherapy, Heinrich-Heine University, Duesseldorf, Germany. christian.luckhaus@lvr.de |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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