| A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes. | |
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MedLine Citation:
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PMID: 9733979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Positron emission tomography (PET) and the dopamine (DA) metabolism tracer, [18F]6-fluoro-L-m-tyrosine (FMT) were used to evaluate the relationship between DA metabolism and the clinical stage of parkinsonism monkeys following either unilateral ICA MPTP infusion or unilateral ICA MPTP infusion and subsequent varying sequential systemic doses of MPTP. Clinical stage corresponded to PET measures of striatal DA metabolism, showing the usefulness of the overlesioned hemiparkinsonian monkey as a stable model of various stages of Parkinson's disease (PD). |
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Authors:
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J L Eberling; W J Jagust; S Taylor; J Bringas; P Pivirotto; H F VanBrocklin; K S Bankiewicz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Brain research Volume: 805 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-11-25 Completed Date: 1998-11-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 259-62 Citation Subset: IM |
Copyright Information:
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Copyright 1998 Elsevier Science B.V. |
Affiliation:
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Center for Functional Imaging, 55-121, Lawrence Berkeley National Laboratory, University of California, 1 Cyclotron Road, Berkeley, CA 94720, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine* Animals Corpus Striatum / metabolism, radionuclide imaging Disease Models, Animal Dopamine / metabolism Dopamine Agents* Macaca mulatta Parkinson Disease, Secondary / chemically induced*, physiopathology*, radionuclide imaging Tomography, Emission-Computed Tyrosine / analogs & derivatives, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agents; 148613-12-1/6-fluoro-3-tyrosine; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 55520-40-6/Tyrosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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