Document Detail


A novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.
MedLine Citation:
PMID:  18951897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We identified a novel inhibitor of growth family member 2 (ING2) isoform, ING2b, which shares exon 2 with ING2a, but lacks the N-terminal p53 binding region. Contrary to ING2a, ING2b's promoter has no p53 binding sites. Consistently, activation of p53 led to suppression of ING2a, leaving ING2b unaffected. Through isoform-specific targeting, we showed that ING2a knockdown suppressed cell growth only in the presence of p53, ING2b knockdown had no effect on cell growth, and knockdown of both induced cell cycle arrest and apoptosis independently of p53. ING2a and ING2b have compensatory roles that protect cells from cell cycle arrest and apoptosis and may be involved in development of chemotherapeutic resistance.
Authors:
Motoko Unoki; Kensuke Kumamoto; Ana I Robles; Jiang Cheng Shen; Zhi-Ming Zheng; Curtis C Harris
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2008-10-23
Journal Detail:
Title:  FEBS letters     Volume:  582     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-02-02     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3868-74     Citation Subset:  IM    
Affiliation:
Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr., Bldg. 37, Rm. 3068, Bethesda, MD 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Apoptosis* / genetics
Binding Sites
Cell Cycle* / genetics
Cell Line
Gene Expression Regulation
Gene Knockdown Techniques
Homeodomain Proteins / genetics,  metabolism*
Humans
Mice
Molecular Sequence Data
Promoter Regions, Genetic
Protein Isoforms / genetics,  metabolism
Receptors, Cytoplasmic and Nuclear / genetics,  metabolism*
Tumor Suppressor Protein p53 / metabolism
Tumor Suppressor Proteins / genetics,  metabolism*
Grant Support
ID/Acronym/Agency:
Z01 BC005795-13/BC/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Homeodomain Proteins; 0/ING2 protein, human; 0/Protein Isoforms; 0/Receptors, Cytoplasmic and Nuclear; 0/Tumor Suppressor Protein p53; 0/Tumor Suppressor Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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