| A novel IKK inhibitor suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration. | |
| | |
MedLine Citation:
|
PMID: 19007316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Objective: Amplification of inflammatory response in the non-infarct area plays an important role in the pathogenesis of ventricular remodeling after myocardial ischemia. Activation of nuclear factor-kappa B (NF-kappaB) is involved in this amplification through a positive feedback loop of pro- inflammatory cytokines. We investigated the efficacy of IKK blockade with IMD-0560, a novel inhibitor of IKK, in a rat myocardial ischemia model. Methods/results: Left coronary artery occlusion (28 days) was carried out in Sprague-Dawley rats. Daily intraperitoneal injections of IMD-0560 (5 mg/kg) were done after the operation. Treatment with IMD-0560 significantly improved cardiac function as indicated by the preservation of fractional shortening and lower serum brain natriuretic peptide level. Histological analysis showed that IMD-0560 treatment suppressed thinning in the infarcted area compared with vehicle-treated hearts. Moreover, in situ zymography showed matrix metalloprotease-9 activity was inhibited in the infarct area. Conclusion: We revealed that the IKK blockade is potent for the suppression of chronic ventricular remodeling after myocardial ischemia. |
| | |
Authors:
|
Shin Wakatsuki; Jun-ichi Suzuki; Masahito Ogawa; Mayumi Masumura; Susumu Muto; Tomoko Shimizu; Kiyoshi Takayama; Akiko Itai; Mitsuaki Isobe |
Related Documents
:
|
14966366 - Enhanced expression of angiopoietin-2 and the tie2 receptor but not angiopoietin-1 or t... 21081276 - Post-myocardial infarction left ventricular myocyte remodeling: are there gender differ... 18808386 - Heart and iron deficiency anaemia in rats with renal insufficiency: the role of hepcidin. 19027736 - Interventional effect of valsartan on expression of inducible camp early repressor and ... 9030996 - Sudden death during holter electrocardiogram monitoring in a patient with variant angina. 6200856 - Atrial trigeminy induced by a normally functioning dvi pacemaker. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Expert opinion on therapeutic targets Volume: 12 ISSN: 1744-7631 ISO Abbreviation: Expert Opin. Ther. Targets Publication Date: 2008 Dec |
Date Detail:
|
Created Date: 2008-11-14 Completed Date: 2009-02-11 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 101127833 Medline TA: Expert Opin Ther Targets Country: England |
Other Details:
|
Languages: eng Pagination: 1469-76 Citation Subset: IM |
Affiliation:
|
Tokyo Medical and Dental University, Department of Cardiovascular Medicine, 1-5-45 Yushima, Bunkyo, Tokyo, Japan,. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Benzamides / pharmacology* Blood Pressure Body Weight Heart Failure / prevention & control* Heart Rate I-kappa B Kinase / antagonists & inhibitors* Male Matrix Metalloproteinases / metabolism* Myocardial Infarction / complications* NF-kappa B / metabolism Rats Rats, Sprague-Dawley Ventricular Remodeling / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Benzamides; 0/N-(2,5-bis(trifluoromethyl)phenyl)-5-bromo-2-hydroxybenzamide; 0/NF-kappa B; EC 2.7.11.10/I-kappa B Kinase; EC 3.4.24.-/Matrix Metalloproteinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrob...
Next Document: Plasma levels of osteopontin before and 24 h after percutaneous coronary intervention.