Document Detail

A novel HLA-DRB1*11 allele, DRB1*1155, was found in a patient through routine DRB1 typing using sequence-specific primers (SSP) and confirmed by allele-specific sequence-based typing.
MedLine Citation:
PMID:  17176450     Owner:  NLM     Status:  MEDLINE    
In comparison with DRB1*1155 allele, DRB1*1103 differs at position 220/221, 'GC' is changed to 'CT', or DRB1*1125 differs at position 210/211, 'AG' is substituted with 'GA'. This results in a single amino acid exchange depending on the closest related allele investigated, whether DRB*1103 codon 74 alanine (GCG) is changed to leucine (CTG) or DRB1*1125 codon 71 arginine (GAG) is replaced with glutamic acid.
K Witter; G Wittmann; A M Lehmeier; T Albert; T Kauke
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Tissue antigens     Volume:  68     ISSN:  0001-2815     ISO Abbreviation:  Tissue Antigens     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-19     Completed Date:  2007-05-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0331072     Medline TA:  Tissue Antigens     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  531-3     Citation Subset:  IM    
Labor für Immungenetik, University Munich, Munich, Germany.
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MeSH Terms
Base Sequence
DNA Primers
HLA-DR Antigens / genetics*
Molecular Sequence Data
Polymerase Chain Reaction
Sequence Analysis, DNA
Reg. No./Substance:
0/DNA Primers; 0/HLA-DR Antigens; 0/HLA-DRB1*1155 antigen; 128338-86-3/HLA-DRB1 antigen

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