Document Detail


A novel GC-rich human macrosatellite VNTR in Xq24 is differentially methylated on active and inactive X chromosomes.
MedLine Citation:
PMID:  1302007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new X chromosome-specific repetitive sequence, a 3 kilobase HindIII clone with a base composition of 63% C+G, has been isolated. The sequence is organized as a hypervariable tandem repeat cluster ranging in size from 150-350 kilobases, with outlying single copies. This locus, designated DXZ4 and mapped to chromosome band Xq24, may consist of as many as 50 variable-length alleles. It represents a class of variable number of tandem repeat polymorphism which may be termed 'macrosatellite'. The cluster is highly methylated on the active X chromosome and hypomethylated on the inactive X.
Authors:
J Giacalone; J Friedes; U Francke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nature genetics     Volume:  1     ISSN:  1061-4036     ISO Abbreviation:  Nat. Genet.     Publication Date:  1992 May 
Date Detail:
Created Date:  1993-06-10     Completed Date:  1993-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9216904     Medline TA:  Nat Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  137-43     Citation Subset:  IM    
Affiliation:
Department of Genetics, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305.
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MeSH Terms
Descriptor/Qualifier:
Base Composition
Base Sequence
Chromosome Mapping
DNA, Satellite / chemistry,  genetics*
Dosage Compensation, Genetic*
Female
Humans
Male
Methylation
Molecular Sequence Data
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid*
X Chromosome*
Chemical
Reg. No./Substance:
0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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