| A novel GC-rich human macrosatellite VNTR in Xq24 is differentially methylated on active and inactive X chromosomes. | |
MedLine Citation:
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PMID: 1302007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new X chromosome-specific repetitive sequence, a 3 kilobase HindIII clone with a base composition of 63% C+G, has been isolated. The sequence is organized as a hypervariable tandem repeat cluster ranging in size from 150-350 kilobases, with outlying single copies. This locus, designated DXZ4 and mapped to chromosome band Xq24, may consist of as many as 50 variable-length alleles. It represents a class of variable number of tandem repeat polymorphism which may be termed 'macrosatellite'. The cluster is highly methylated on the active X chromosome and hypomethylated on the inactive X. |
Authors:
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J Giacalone; J Friedes; U Francke |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Nature genetics Volume: 1 ISSN: 1061-4036 ISO Abbreviation: Nat. Genet. Publication Date: 1992 May |
Date Detail:
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Created Date: 1993-06-10 Completed Date: 1993-06-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9216904 Medline TA: Nat Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 137-43 Citation Subset: IM |
Affiliation:
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Department of Genetics, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Base Composition Base Sequence Chromosome Mapping DNA, Satellite / chemistry, genetics* Dosage Compensation, Genetic* Female Humans Male Methylation Molecular Sequence Data Polymorphism, Genetic Repetitive Sequences, Nucleic Acid* X Chromosome* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Satellite |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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