Document Detail

A normative study of obstetric complications associated with fetal trisomy 18.
MedLine Citation:
PMID:  8732559     Owner:  NLM     Status:  MEDLINE    
Our objective was to determine whether the cesarean section rate and amniotic fluid lecithin-sphingomyelin ratio (L/S ratio) associated with fetal trisomy 18 are different from those associated with euploid pregnancies. Forty-nine trisomy 18 pregnancies were identified and their records were reviewed. Of the 22 live-born infants, 15 (68%) were delivered by cesarean section. The overall cesarean section rate for the institution ranged from 19.1% to 22.6%. In five patients with gestational ages between 35 and 38 weeks who had amniocentesis as part of the evaluation of intrauterine growth retardation, the L/S ratios were < or = 1.8. These data confirm that undiagnosed trisomy 18 pregnancies are associated with an increased cesarean section rate. Further, trisomy 18 fetuses appear to have delayed maturation of the L/S ratio. These results reinforce the importance of a karyotypic evaluation of selected pregnancies complicated by intrauterine growth retardation, even in the third trimester, and suggest that the prenatal diagnosis of trisomy 18 is of obstetric importance.
D N Saller; C E Oyer; J Star; J A Canick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  16     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:    1996 Mar-Apr
Date Detail:
Created Date:  1996-11-05     Completed Date:  1996-11-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  117-20; quiz 121-2     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Women and Infants Hospital, Providence, R.I., USA.
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MeSH Terms
Amniotic Fluid / metabolism
Cesarean Section / statistics & numerical data
Chromosomes, Human, Pair 18*
Fetal Diseases / diagnosis*,  genetics
Fetal Growth Retardation
Phosphatidylcholines / metabolism
Pregnancy Complications / prevention & control*
Pregnancy Outcome*
Pregnancy Trimester, Third
Prenatal Diagnosis* / methods
Sphingomyelins / metabolism
Trisomy / diagnosis*
Reg. No./Substance:
0/Phosphatidylcholines; 0/Sphingomyelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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