Document Detail


The normal distribution of PRNP codon 129 polymorphism in the Moroccan population (Arabs and Casablanca residents).
MedLine Citation:
PMID:  18191917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The common prion protein gene (PRNP) codon 129 polymorphism is a strong susceptibility factor for human prion diseases. In this study, we examined the allelic variation of methionine and valine at codon 129 in 147 subjects representing the normal Moroccan population. The sharing of the genotype was 57.1% for Methionine-Methionine (MM), 36% for Methionine-Valine (MV), and 6, 8% for Valine-Valine (VV). These results are indeed intermediate between those discovered at the European and Asian populations. However, and for a better assessment of the risk to develop prion diseases in the Moroccan population, the survey of the frequency of the codon 219 polymorphism is required.
Authors:
S Nadifi; I Slassi; K M El Hachimi; B Gazzaz; H Bellayou; K Raddaoui; J L Laplanche
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Publication Detail:
Type:  Journal Article     Date:  2008-01-09
Journal Detail:
Title:  Pathologie-biologie     Volume:  56     ISSN:  0369-8114     ISO Abbreviation:  Pathol. Biol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-28     Completed Date:  2008-09-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0265365     Medline TA:  Pathol Biol (Paris)     Country:  France    
Other Details:
Languages:  eng     Pagination:  133-6     Citation Subset:  IM    
Affiliation:
Genetic and Molecular Pathology Laboratory, Medical School, Hassan II University, Casablanca, Morocco. labgenmed@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Arabs / genetics
European Continental Ancestry Group / genetics
Genotype
Humans
Methionine
Morocco
Normal Distribution
Polymorphism, Genetic*
Prion Diseases / genetics
Prions / genetics*
Valine
Chemical
Reg. No./Substance:
0/PRNP protein, human; 0/Prions; 63-68-3/Methionine; 7004-03-7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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