| The normal antireflux mechanism. | |
| | |
MedLine Citation:
|
PMID: 11787959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The normal antireflux mechanism consists of several components, any one of which may malfunction and render an individual prone to the development of GERD. The LES is clearly the most important component because gastroesophageal reflux almost always occurs when the sphincter pressure equals that of the stomach. Usually, an LES pressure of just 2 to 3 mm Hg above intragastric pressure is sufficient to prevent reflux. Other factors certainly play significant ancillary roles in preventing reflux. In the absence of a hiatal hernia, the crural fibers of the diaphragm serve as an "extrinsic" sphincter. Furthermore, the unique anatomy of the proximal stomach (e.g., the angle of His, mucosal flap valve, posterolateral location of the fundus) serves to keep gastric contents away from the gastroesophageal junction, making it less likely for reflux to occur when the LES relaxes. When a hiatal hernia is present, these factors are lost, and the hernia sac provides a reservoir for gastric juices with ready access to the LES. Finally, some degree of reflux occurs in all individuals, but esophageal clearance and acid neutralization provide an important last line of defense. |
| | |
Authors:
|
W G Paterson |
Related Documents
:
|
7557579 - Differences in colonic tone and phasic response to a meal in the transverse and sigmoid... 748089 - A hydraulic behavior of the mucosal structure of the intramural common bile duct. an ex... 463489 - Functional analysis of organic sphincter systems by elastance-measurement. evaluation o... 8305269 - Simultaneous videoradiography and computerized pharyngeal manometry--videomanometry. 9733609 - Choledochosphincter inhibitory reflex: identification of the reflex in dogs and its sig... 15086879 - Abnormal rectal motor physiology in patients with irritable bowel syndrome. 7032559 - Closed-circuit halothane and enflurane using an in-circle goldman vaporizer. 2628499 - Clinical evaluation of semiautomatic and automatic devices for home blood pressure meas... 11368469 - Pulsatility of ascending aortic blood pressure waveform is associated with an increased... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Chest surgery clinics of North America Volume: 11 ISSN: 1052-3359 ISO Abbreviation: Chest Surg. Clin. N. Am. Publication Date: 2001 Aug |
Date Detail:
|
Created Date: 2002-01-11 Completed Date: 2002-05-28 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 9208495 Medline TA: Chest Surg Clin N Am Country: United States |
Other Details:
|
Languages: eng Pagination: 473-83 Citation Subset: IM |
Affiliation:
|
Queen's University, Hotel Dieu Hospital, Kingston, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Esophagogastric Junction
/
anatomy & histology*,
physiology* Gastroesophageal Reflux / physiopathology* Humans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Opposite effects of mast cell degranulation by compound 48/80 on peritoneal inflammation in Swiss an...
Next Document: Gastroesophageal reflux disease pathophysiology.