Document Detail


A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands.
MedLine Citation:
PMID:  19768813     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Marijuana use activates cannabinoid receptors (CB-Rs) producing several behavioral effects related to addiction, mood, and appetite. We investigated the association between CNR2 gene, which encodes cannabinoid CB2 receptor (CB2-R) and eating disorders in 204 subjects with eating disorders and 1876 healthy volunteers in Japanese population. The effect of treatment with CB2-R ligands on mouse food consumption was also determined. The CB2-R ligands used suppressed food intake in a time- and strain-dependent manner when food was available ad libitum and during the 12-h fast except, AM 630-the CB2-R antagonist that stimulated food consumption in food-deprived mice. There is an association between the R63Q polymorphism of the CNR2 gene and eating disorders (P = 0.04; Odds ratio 1.24, 95% CI, (1.01-1.53). These results suggest that cannabinoid CB2-R is involved in the endocannabinoid signaling mechanisms associated with the regulation of food intake and in eating disorders.
Authors:
H Ishiguro; O Carpio; Y Horiuchi; A Shu; S Higuchi; N Schanz; R Benno; T Arinami; E S Onaivi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Synapse (New York, N.Y.)     Volume:  64     ISSN:  1098-2396     ISO Abbreviation:  Synapse     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-11-09     Completed Date:  2010-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806914     Medline TA:  Synapse     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-6     Citation Subset:  IM    
Affiliation:
Department of Medical Genetics, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8575, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Regulation / genetics*
Eating
Eating Disorders / genetics*
Female
Genetic Predisposition to Disease*
Humans
Ligands
Male
Mice
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Receptor, Cannabinoid, CB2 / genetics*
Chemical
Reg. No./Substance:
0/Ligands; 0/Receptor, Cannabinoid, CB2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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