Document Detail


A nonsurgical canine model of chronic left ventricular myocardial dysfunction.
MedLine Citation:
PMID:  6859279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A simple technique of producing left ventricular myocardial damage accompanied by chronic complete heart block in dogs is described. The method is accomplished by repetitive transmyocardial DC shock with a guide wire introduced percutaneously and positioned in the left ventricle along the intraventricular septum and an external paddle at the left ventricular apex. Twelve weeks after the procedure significant hemodynamic changes included a fall in heart rate from a control of 76 +/- 19 (SD) to 43 +/- 9 beats/min (P less than 0.001), a rise in left ventricular filling pressure from 9 +/- 4 to 28 +/- 10 mmHg (P less than 0.001), and a fall in cardiac output from 3.1 +/- 1 to 2.3 +/- 0.6 l/min (P less than 0.05). Weekly echocardiography revealed a progressive increase in left ventricular end-diastolic diameter from 3.56 +/- 0.72 to 4.84 +/- 0.47 cm (P less than 0.01). Survival rate was 70%. Therefore, this relatively noninvasive technique is an effective means of producing chronic left ventricular myocardial dysfunction in the dog.
Authors:
P F Carlyle; J N Cohn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  244     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-07-29     Completed Date:  1983-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H769-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Cardiac Output
Cardiomyopathies / physiopathology*
Disease Models, Animal
Dogs
Heart Rate
Heart Ventricles / physiopathology
Myocardium / pathology
Stroke Volume
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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