| The nonstop transvesical cystometrogram in urethane-anesthetized rats: a simple procedure for quantitative studies on the various phases of urinary bladder voiding cycle. | |
| | |
MedLine Citation:
|
PMID: 3702468 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A new cystometric procedure that involves a nonstop transvesical (through a needle inserted into the bladder dome) infusion of saline in urethane-anesthetized rats is described. This permits the obtainment of a series of repetitive voiding cycles in both male and female rats. Recording at high-chart speed permits quantitative measurements of the various phases of the voiding cycle. Micturition was almost invariably associated with appearance, during a sustained increase of intravesical pressure, of a series of high-frequency oscillations, which were paralleled by a stream-like emission of the infused fluid. Micturition was not observed after topical tetrodotoxin, after bilateral transection of pelvic nerves, or in acute spinal rats. Intravenous hexamethonium produced a dose-related impairment of the voiding cycle, and, at high doses, suppressed micturition, and overflow incontinence ensued. The experimental procedure described herein appears to be suitable for physiopharmacological studies dealing with regulation of voiding cycle. |
| | |
Authors:
|
C A Maggi; P Santicioli; A Meli |
Related Documents
:
|
16304628 - Trigeminal transition zone/rostral ventromedial medulla connections and facilitation of... 11524348 - The release of spinal prostaglandin e2 and the effect of nitric oxide synthetase inhibi... 6185888 - Coexistence of cholecystokinin- and substance p-like peptides in neurons of the dorsal ... 12354698 - Decreased gfap-mrna expression in spinal cord of cobalamin-deficient rats. 19465868 - Bilirubin impairs intestinal regrowth following massive small bowel resection in a rat ... 2922768 - Toxicity studies with quinine hydrochloride. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of pharmacological methods Volume: 15 ISSN: 0160-5402 ISO Abbreviation: J Pharmacol Methods Publication Date: 1986 Apr |
Date Detail:
|
Created Date: 1986-05-23 Completed Date: 1986-05-23 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7806596 Medline TA: J Pharmacol Methods Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 157-67 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anesthesia Animals Cystoscopes Female Hexamethonium Compounds / pharmacology Male Muscle Contraction / drug effects Muscle, Smooth / physiology Pressure Rats Rats, Inbred Strains Sex Factors Urethane Urinary Bladder / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Hexamethonium Compounds; 51-79-6/Urethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Experimental model for pharmacokinetic studies during continuous peritoneal dialysis in the rabbit.
Next Document: In vitro evaluation of nucleoside transport inhibition in vivo.