Document Detail

A nonpeptide provides insight into mechanisms that regulate Drosophila melanogaster heart contractions.
MedLine Citation:
PMID:  14706539     Owner:  NLM     Status:  MEDLINE    
Here we report the effect of a nonpeptide, benzethonium chloride (bztc), on Drosophila melanogaster larval, pupal, and adult heart rates in vivo. Benzethonium chloride reduced the frequency of spontaneous contractions in the D. melanogaster pupal heart, but not in the larval heart or the adult heart as measured in noninvasive whole animal preparations. When applied directly to the D. melanogaster heart, in the absence of hemolymph, bztc reduced the frequency of spontaneous contractions in larval, pupal, and adult hearts. These findings are consistent with the conclusion that bztc acts through or is regulated by different mechanisms in these three developmental stages. An alternative explanation is that larval hemolymph and adult hemolymph contain a material that interferes with the effect of the nonpeptide on heart contractions. Bztc mimicked the effect of the peptide dromyosuppressin (DMS) on the heart at an equivalent concentration; in contrast, 103-fold more nonpeptide is required to mimic the effect of DMS on fly gut. These findings are consistent with the presence of tissue-specific myosuppressin receptors or mechanisms.
Melissa Mispelon; Kiran Thakur; Leslie Chinn; Ryan Owen; Ruthann Nichols
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  24     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2004-01-06     Completed Date:  2005-01-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1599-605     Citation Subset:  IM    
Undergraduate Cell and Molecular Biology Program, Biological Chemistry Department, University of Michigan Medical School, 4444 Medical Sciences Building I, Ann Arbor, MI 48109-0606, USA.
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MeSH Terms
Aging / physiology
Benzethonium / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Drosophila melanogaster / drug effects*,  physiology
Heart / drug effects*,  physiology
Larva / drug effects,  physiology
Myocardial Contraction / drug effects*
Pupa / drug effects,  physiology
Grant Support
Reg. No./Substance:

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