Document Detail

A nonlinear model for transduction in hair cells.
MedLine Citation:
PMID:  2422148     Owner:  NLM     Status:  MEDLINE    
Based on the experimental observations of the mechano-electrical transduction in hair cells, we formulate a model of the receptor potential utilizing a simple model circuit and ideas of stretch activation that have been developed for other mechanoreceptors. The stereociliary displacement-response relation is developed based on the cilia crosslinking, thus incorporating notions of bidirectional sensitivity, asymmetry, saturation, and adaptation into the model. We then give some simulation results involving periodic stimuli to the hair bundle as well as current stimuli of study latency behavior and other qualitative properties of the model.
J Bell; M H Holmes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  21     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1986  
Date Detail:
Created Date:  1986-06-11     Completed Date:  1986-06-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  97-108     Citation Subset:  IM    
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MeSH Terms
Biophysical Phenomena
Calcium / physiology
Cilia / physiology
Guinea Pigs
Hair Cells, Auditory / physiology*
Ion Channels / physiology
Membrane Potentials
Microvilli / physiology
Models, Neurological*
Rana catesbeiana
Sensory Receptor Cells / physiology*
Reg. No./Substance:
0/Ion Channels; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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