Document Detail

A noninvasive protocol for anterior temporal lobectomy.
MedLine Citation:
PMID:  1736176     Owner:  NLM     Status:  MEDLINE    
We report the results of a protocol for choosing candidates for temporal lobectomy using a standard battery of objective tests without intracranial electrodes. We assigned each test a level of importance, and an algorithm was used to determine whether temporal lobectomy could be performed. Fifty-one patients (total pool, 103 patients) met protocol requirements and had an anterior temporal lobectomy with a mean follow-up of 39.4 months (range, 21 to 64 months), most remaining on anticonvulsant therapy. Eighty percent are seizure free, 12% have less than 3 seizures per year or only nocturnal seizures, and 8% have greater than 80% reduction in seizure frequency. One-third of patients who failed protocol criteria did not have temporal lobe seizures when studied with intracranial electrodes. We analyzed and modified the algorithm after comparing these patients with others who were poor candidates for temporal lobectomy. We conclude that this protocol is effective and recommend using such an objective algorithm.
M R Sperling; M J O'Connor; A J Saykin; C A Phillips; M J Morrell; P A Bridgman; J A French; N Gonatas
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  42     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-03-12     Completed Date:  1992-03-12     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  416-22     Citation Subset:  AIM; IM    
Comprehensive Epilepsy Center, Graduate Hospital, Philadelphia, PA 19146.
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MeSH Terms
Action Potentials / physiology
Clinical Protocols
Epilepsy, Complex Partial / physiopathology,  surgery*
Magnetic Resonance Imaging
Temporal Lobe / physiopathology,  surgery*
Grant Support

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