| A nonhuman primate model of excessive alcohol intake. Personality and neurobiological parallels of type I- and type II-like alcoholism. | |
| | |
MedLine Citation:
|
PMID: 9122496 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Developmental, biochemical, and behavioral concomitants of voluntary excessive alcohol consumption were investigated using a nonhuman primate model. Studies were designed to investigate potential neurobiological and behavioral parallels of Cloninger's subtypes of type I and type II alcoholism in nonhuman primates. The studies have shown that a subpopulation of primates chronically consume intoxicating amounts of alcohol. Subjects that chronically consume intoxicating amounts of alcohol often exhibit neurobiological and behavioral features that were predicted by Cloninger's model for subtypes of alcoholism among humans. Investigations showed that behavior patterns and biological indices that characterize high anxiety, whether constitutionally or stress induced, were correlated with high rates of alcohol consumption, consistent with predictions for type I alcoholism. Early untoward rearing experiences that increased anxiety increased the probability that subjects would chronically drink alcohol to intoxication. Investigations of type II-like alcohol consumption patterns focused on subjects with low central nervous system (CNS) serotonin functioning [as measured by reduced cerebrospinal fluid (CSF) concentrations of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA)]. CSF 5-HIAA in infancy was shown to be a relatively stable neurobiological trait across development into adulthood. An individual CSF 5-HIAA concentration in infancy was shown to be a consequence of paternal and maternal genetic influences. Early parental neglect reduced CSF 5-HIAA concentrations. Low CSF 5-HIAA and CNS norepinephrine functioning were shown to predict excessive alcohol consumption in adolescence. Behaviorally, subjects with low CSF 5-HIAA demonstrated impaired impulse control, which resulted in excessive and inappropriate aggression, infrequent and inept social behaviors, low social status, social isolation and expulsion from social groups at an early age, and high rates of early mortality. With some exceptions, these findings were consistent with predictions from Cloninger's type II model of excessive alcohol consumption among men who exhibit impaired impulse control and violent and antisocial behaviors. |
| | |
Authors:
|
J D Higley; M Linnoila |
Related Documents
:
|
20712596 - The pathology of alcohol hangover. 20148776 - Human and laboratory rodent low response to alcohol: is better consilience possible? 15881556 - Descriptive study of chronic calcific pancreatitis in sri lanka. 10661676 - Subsensitive alpha-2-adrenoceptor function in male alcohol-dependent individuals during... 266596 - Hla b27 and sacroiliitis in pima indians--association in males only. 13678756 - The prognostic value of high-sensitive c-reactive protein and cardiac troponin t in you... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism Volume: 13 ISSN: 0738-422X ISO Abbreviation: Recent Dev Alcohol Publication Date: 1997 |
Date Detail:
|
Created Date: 1997-04-22 Completed Date: 1997-04-22 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 8301996 Medline TA: Recent Dev Alcohol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 191-219 Citation Subset: IM |
Affiliation:
|
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Poolesville, Maryland 20837, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alcoholic Intoxication
/
classification,
genetics,
physiopathology*,
psychology Alcoholism / classification, genetics, physiopathology*, psychology Animals Arousal / drug effects, physiology Brain / physiopathology Disease Models, Animal Female Humans Hydroxyindoleacetic Acid / cerebrospinal fluid Macaca mulatta Male Norepinephrine / physiology Personality* / genetics Serotonin / physiology Social Environment Species Specificity |
| Chemical | |
Reg. No./Substance:
|
50-67-9/Serotonin; 51-41-2/Norepinephrine; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serotonin in early-onset alcoholism.
Next Document: Effects of alcohol on human aggression. Validity of proposed explanations.