Document Detail

A non-synonymous mutation in a conserved site of the MTTP gene is strongly associated with protein activity and fatty acid profile in pigs.
MedLine Citation:
PMID:  19496770     Owner:  NLM     Status:  MEDLINE    
Despite the economic interest of the fatty acid profile in pigs, no gene has been convincingly associated with this trait so far. Here, the porcine microsomal triglyceride transfer protein (MTTP) gene, which plays a crucial role in the assembly of nascent lipoproteins, has been analysed as a positional candidate gene for a QTL affecting the fatty acid composition that was previously identified on chromosome 8 in an Iberian by Landrace F(2) cross. By resequencing a panel of different breeds, a non-synonymous polymorphism in a conserved residue of the lipid transfer domain of MTTP was identified. Association analyses with this polymorphism showed a strong association with the fatty acid composition of porcine fat, much stronger than the QTL effect, in the F(2) cross and in a synthetic Sino-European line. In addition, in vitro activity assays in liver protein extracts have shown that this mutation is also associated with the lipid transfer activity of the MTTP protein (P < 0.1). These results suggest that the detected polymorphism is a potential causal factor of the fatty acid composition QTL. There appears to be an interaction between the porcine MTTP genotype and the type of fat source in the pig diet, which would agree with the previous results on the biology of MTTP biology.
J Estellé; A I Fernández; M Pérez-Enciso; A Fernández; C Rodríguez; A Sánchez; J L Noguera; J M Folch
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-03
Journal Detail:
Title:  Animal genetics     Volume:  40     ISSN:  1365-2052     ISO Abbreviation:  Anim. Genet.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605704     Medline TA:  Anim Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  813-20     Citation Subset:  IM    
Departament de Ciència Animal i dels Aliments, Facultat de Veterinària, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
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MeSH Terms
Carrier Proteins / genetics*
Fatty Acids / analysis
Lipoproteins / analysis,  metabolism*
Liver / chemistry
Quantitative Trait Loci
Sus scrofa / genetics*
Reg. No./Substance:
0/Carrier Proteins; 0/Fatty Acids; 0/Lipoproteins; 0/microsomal triglyceride transfer protein

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