Document Detail

The non-steroidal anti-inflammatory drug diclofenac is readily biodegradable in agricultural soils.
MedLine Citation:
PMID:  20952049     Owner:  NLM     Status:  MEDLINE    
Diclofenac, 2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetic acid, is an important non-steroidal anti-inflammatory drug widely used for human and animals to reduce inflammation and pain. Diclofenac could potentially reach agricultural lands through the application of municipal biosolids or wastewater, and in the absence of any environmental fate data, we evaluated its persistence in agricultural soils incubated in the laboratory. (14)C-Diclofenac was rapidly mineralized without a lag when added to soils varying widely in texture (sandy loam, loam, clay loam). Over a range of temperature and moisture conditions extractable (14)C-diclofenac residues decreased with half lives <5days. No extractable transformation products were detectable by HPLC. Diclofenac mineralization in the loam soil was abolished by heat sterilization. Addition of biosolids to sterile or non-sterile soil did not accelerate the dissipation of diclofenac. These findings indicate that diclofenac is readily biodegradable in agricultural soils.
Abdul Jabbar Al-Rajab; Lyne Sabourin; David R Lapen; Edward Topp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-16
Journal Detail:
Title:  The Science of the total environment     Volume:  409     ISSN:  1879-1026     ISO Abbreviation:  Sci. Total Environ.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2010-12-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  78-82     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2010. Published by Elsevier B.V. All rights reserved.
Agriculture and Agri-Food Canada, London, ON, Canada N5V 4T3.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / analysis,  metabolism*
Biodegradation, Environmental
Diclofenac / analysis,  metabolism*
Soil / chemistry
Soil Microbiology
Soil Pollutants / analysis,  metabolism*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Soil; 0/Soil Pollutants; 15307-86-5/Diclofenac

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