Document Detail

The non-peptide neuroprotective agents SR 57746A interacts with neurotrophin 3 to induce differentiation in the PC12 cell-line.
MedLine Citation:
PMID:  9600726     Owner:  NLM     Status:  MEDLINE    
SR 57746A (1-(2beta-naphthylethyl)-4-(3-trifluoromethylphenyl)-1,2,5,6 -tetrahydropyridine hydrochloride) is a neuroprotective compound which potentiates nerve-growth factor (NGF)-induced differentiation in PC12 cells. We have evaluated the interaction of SR 57746A with the other members of the neurotrophin family in this cell-line. In contrast with NGF, neurotrophin-3 did not increase the differentiation of PC12 cells. However, the association of SR 57746A with neurotrophin-3 significantly increased neurite outgrowth. No significant activity on neurite outgrowth was observed with brain-derived neurotrophic factor or neurotrophin-4, either alone or combined with SR 57746A. These results indicate that as well as potentiating the effect of NGF SR 57746A enables neurotrophin-3, which alone is inactive, to increase the differentiation of these cells.
J Fournier; G Boutot; P E Keane; J P Maffrand; G Le Fur; P Soubrié
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  50     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-07-16     Completed Date:  1998-07-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  323-7     Citation Subset:  IM    
Sanofi Recherche, Toulouse, France.
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MeSH Terms
Brain-Derived Neurotrophic Factor / pharmacology
Cell Differentiation / drug effects*
Culture Media, Serum-Free
Drug Synergism
Naphthalenes / pharmacology*
Nerve Growth Factors / pharmacology*
Neurites / drug effects
Neuroprotective Agents / pharmacology*
Neurotrophin 3
PC12 Cells
Pyridines / pharmacology*
Serotonin Agonists / pharmacology*
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Culture Media, Serum-Free; 0/Naphthalenes; 0/Nerve Growth Factors; 0/Neuroprotective Agents; 0/Neurotrophin 3; 0/Pyridines; 0/Serotonin Agonists; 135354-02-8/xaliproden; 143551-63-7/neurotrophin 4

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