Document Detail

The non-invasive determination of cardiac output in children: a three-breath technique.
MedLine Citation:
PMID:  3136684     Owner:  NLM     Status:  MEDLINE    
In this study, the cardiac output of 11 children (5 days to 18 yr of age) was measured following cardiopulmonary bypass. Standard dye dilution cardiac outputs and an indirect Fick-CO2 technique were simultaneously determined. A rebreathing maneuver is described to estimate the oxygenated mixed venous PCO2 (PvCO2). This estimate of PvCO2 was combined with the end tidal PCO2 and CO2 production to give a non-invasive Fick estimate of the cardiac output. Non-invasive cardiac outputs correlated well with those measured by dye-dilution (r2 = 0.94) over a range of cardiac outputs from 490-7280 ml/min. All non-invasive determinations were within 15% of the line of identity, and within 22% of averaged replicate dye-dilution values. Our results agree with previous comparisons of indirect Fick-CO2 methods with invasive determinations of cardiac output. These data suggest that the indirect Fick-CO2 technique offers a rapid, non-invasive alternative to invasive monitoring of cardiac output.
W D Morton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesiology     Volume:  69     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-22     Completed Date:  1988-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  223-6     Citation Subset:  AIM; IM    
Department of Anesthesia, Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Carbon Dioxide / blood*,  metabolism
Cardiac Output*
Child, Preschool
Dye Dilution Technique
Forced Expiratory Flow Rates
Infant, Newborn
Oxygen / blood
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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