Document Detail

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy.
MedLine Citation:
PMID:  21081959     Owner:  NLM     Status:  In-Data-Review    
Background/Objectives:To determine the impact of a not hydrolyzed fermented infant formula containing heat-killed Bifidobacterium breve C50 and Streptococcus thermophilus 065 (HKBBST) on the incidence of allergy-like events during the first 2 years of life in children at high risk of atopy.Subjects/Methods:This multicenter, randomized, double-blind, controlled study included infants at high risk of atopy. Infants used HKBBST or a standard infant formula (SIF) since birth until 1 year of age, and were followed at 4, 12 and 24 months after birth. Skin prick tests (SPTs) for six foods and six aeroallergens were systematically performed and adverse events (AEs) were recorded. In case of potentially allergic AE (PAAE), allergy could be further tested by SPT, patch tests and quantification of specific IgEs. If cow's milk allergy (CMA) was suspected, an oral challenge could also be performed.Results:The study included 129 children, 63 were randomized to SIF, 66 to HKBBST. The use of HKBBST milk did not alter the proportion of CMA but decreased the proportion of positive SPT to cow's milk (1.7 vs 12.5%, P=0.03), and the incidence of digestive (39 vs 63%, P=0.01) and respiratory potentially allergic AEs (7 vs 21%, P=0.03) at 12 months, and that of respiratory PAAEs at 24 months (13 vs 35%, P=0.01).Conclusions:HKBBST decreased the incidence of PAAEs in children with family history of atopy, during the first months of life and after the formula was stopped. Oral tolerance to cow's milk in infants at high risk of atopy may therefore be improved using not hydrolyzed fermented formulae.
M Morisset; C Aubert-Jacquin; P Soulaines; D-A Moneret-Vautrin; C Dupont
Related Documents :
21284459 - Analysis of the risk of shunt failure or infection related to cerebrospinal fluid cell ...
21151009 - Acute neurological findings in a national cohort of neonates with severe neonatal hyper...
15539879 - In utero meconium suctioning may prevent meconium aspiration.
9056049 - Prevention of amlodipine absorption by activated charcoal: effect of delay in charcoal ...
15866049 - Two separate metalloproteinase activities are responsible for the shedding and processi...
15214359 - Ximelagatran for prevention and treatment of venous thromboembolism.
2317089 - Birthweight of infants born to hispanic women employed in agriculture.
24303069 - The enterocyte-associated intestinal microbiota of breast-fed infants and adults respon...
23412969 - Probiotics and necrotizing enterocolitis: finding the missing pieces of the probiotic p...
Publication Detail:
Type:  Journal Article     Date:  2010-11-17
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  65     ISSN:  1476-5640     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  175-83     Citation Subset:  IM    
Médecine Interne, Immunologie Clinique et Allergologie, CHU de Nancy, EA 3999 'Allergic Diseases: Diagnostic and Therapy', Nancy University, Nancy, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of four nutritional screening tools to detect nutritional risk in hospitalized patients: ...
Next Document:  Let's see how tmRNA rescues a stuck ribosome.