Document Detail

A nomenclature system for the aldo-keto reductase superfamily.
MedLine Citation:
PMID:  9059665     Owner:  NLM     Status:  MEDLINE    
As new members of the AKR superfamily are identified the need for a systematic and expandable nomenclature has risen, especially since some members of the superfamily have multiple names based on substrate specificity. We have proposed a nomenclature system for the AKR superfamily that is similar to the P450 system but based on amino acid sequence comparisons instead of nucleotide sequence comparisons. Our system uses percent amino acid identities to delineate families and subfamilies within the larger superfamily. Although there are not as many AKRs as P450s, having a flexible nomenclature system will allow for easy incorporation of new proteins into the superfamily.
J M Jez; T G Flynn; T M Penning
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  414     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  1997  
Date Detail:
Created Date:  1997-05-15     Completed Date:  1997-05-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  579-600     Citation Subset:  IM    
Department of Biochemistry and Biophysics, University of Pennsylvania Medical School, Philadelphia 19104, USA.
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MeSH Terms
3-Hydroxysteroid Dehydrogenases / chemistry*,  classification*
3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
Amino Acid Sequence
Databases, Factual
Fungi / enzymology
Molecular Sequence Data
Oxidoreductases / chemistry*,  classification*
Plants / enzymology
Protein Structure, Secondary
Sequence Homology, Amino Acid
Terminology as Topic*
Reg. No./Substance:
EC 1.-/Oxidoreductases; EC 1.1.-/3-Hydroxysteroid Dehydrogenases; EC Dehydrogenase (B-Specific)

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