| A nomenclature system for the aldo-keto reductase superfamily. | |
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MedLine Citation:
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PMID: 9059665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As new members of the AKR superfamily are identified the need for a systematic and expandable nomenclature has risen, especially since some members of the superfamily have multiple names based on substrate specificity. We have proposed a nomenclature system for the AKR superfamily that is similar to the P450 system but based on amino acid sequence comparisons instead of nucleotide sequence comparisons. Our system uses percent amino acid identities to delineate families and subfamilies within the larger superfamily. Although there are not as many AKRs as P450s, having a flexible nomenclature system will allow for easy incorporation of new proteins into the superfamily. |
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Authors:
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J M Jez; T G Flynn; T M Penning |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 414 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-05-15 Completed Date: 1997-05-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 579-600 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Biophysics, University of Pennsylvania Medical School, Philadelphia 19104, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxysteroid Dehydrogenases
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chemistry*,
classification* 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) Amino Acid Sequence Animals Databases, Factual Fungi / enzymology Humans Molecular Sequence Data Oxidoreductases / chemistry*, classification* Phylogeny Plants / enzymology Protein Structure, Secondary Sequence Homology, Amino Acid Software Terminology as Topic* |
| Chemical | |
Reg. No./Substance:
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EC 1.-/Oxidoreductases; EC 1.1.-/3-Hydroxysteroid Dehydrogenases; EC 1.1.1.50/3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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