Document Detail


Is nitric oxide the only endothelium-derived relaxing factor in canine femoral veins?
MedLine Citation:
PMID:  2513730     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nitric oxide may be an endothelium-derived relaxing factor in systemic arteries and pulmonary veins. The endothelium-derived relaxing factor of systemic veins has not been characterized. Experiments were designed to determine whether the endothelium-derived relaxing factor of systemic veins shared chemical properties and mechanisms of action with nitric oxide. Rings of the canine femoral vein with and without endothelium were suspended in organ chambers for the measurement of isometric force. In rings without endothelium, relaxations to nitric oxide were augmented by superoxide dismutase plus catalase and were inhibited by hemoglobin, methylene blue, and LY 83583. The endothelium-dependent relaxations to acetylcholine and A23187 were not augmented by superoxide dismutase plus catalase but were inhibited by hemoglobin and only moderately reduced by either methylene blue or LY 83583. Relaxations to sodium nitroprusside were not inhibited by methylene blue and LY 83583. Relaxations to sodium nitroprusside were inhibited by ouabain and K+-free solution; those to nitric oxide were not. These results indicate that although the endothelium-derived relaxing factor released from canine systemic veins shares some chemical properties with nitric oxide, the mechanism by which relaxations are induced by the two differ. A factor dissimilar to nitric oxide but acting like sodium nitroprusside may be released by the endothelium of canine systemic veins.
Authors:
V M Miller; P M Vanhoutte
Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  257     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-02-02     Completed Date:  1990-02-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1910-6     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Aminoquinolines / pharmacology
Animals
Calcimycin / pharmacology
Catalase / pharmacology
Dinoprost / pharmacology
Dogs
Femoral Vein / drug effects,  physiology*
Hemoglobins / physiology
Indomethacin / pharmacology
Methylene Blue / pharmacology
Muscle, Smooth, Vascular / drug effects,  physiology*
Nitric Oxide / blood*
Norepinephrine / pharmacology
Ouabain / pharmacology
Potassium / pharmacology
SRS-A / antagonists & inhibitors
Superoxide Dismutase / pharmacology
Vasodilation / drug effects
Grant Support
ID/Acronym/Agency:
HL-31183/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Aminoquinolines; 0/Hemoglobins; 0/SRS-A; 10102-43-9/Nitric Oxide; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 52665-69-7/Calcimycin; 53-86-1/Indomethacin; 551-11-1/Dinoprost; 61-73-4/Methylene Blue; 630-60-4/Ouabain; 7440-09-7/Potassium; 91300-60-6/6-anilino-5,8-quinolinedione; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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