Document Detail

Is nitric oxide involved in the pathophysiology of essential hyperhidrosis?
MedLine Citation:
PMID:  17910708     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Essential hyperhidrosis (EH) is a disorder of excessive, bilateral, and relatively symmetric sweating occurring in the axillae, palms, soles, or craniofacial region without obvious etiology. The expression of endothelial nitric oxide synthase (eNOS) in eccrine clear cells, reported by an immunohistochemical technique, has suggested that nitric oxide (NO) may play a role in the physiology of production and/or excretion of sweat in the human skin eccrine gland. AIM: To determine plasma NO levels in patients with EH and healthy controls. METHODS: We assessed the levels of plasma NO in patients with EH (n = 31) in comparison with those in age- and sex-matched healthy controls (n = 28). Total nitrite (nitrite + nitrate) was measured by a spectrophotometer at 545 nm after the conversion of nitrate to nitrite by copperized cadmium granules. RESULTS: Plasma NO levels were found to be significantly increased in EH patients in comparison with the control group (P = 0.0001). CONCLUSIONS: These findings indicate a possible role of increased plasma NO levels in the pathophysiology of EH.
Semsettin Karaca; Mustafa Kulac; Efkan Uz; Irfan Barutcu; H Ramazan Yilmaz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of dermatology     Volume:  46     ISSN:  0011-9059     ISO Abbreviation:  Int. J. Dermatol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-03     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1027-30     Citation Subset:  IM    
Department of Dermatology, School of Medicine, Afyon Kocatepe University, Afyon, Turkey.
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MeSH Terms
Case-Control Studies
Hyperhidrosis / blood*,  etiology
Middle Aged
Nitrates / blood
Nitric Oxide / blood*,  metabolism
Nitrites / blood
Statistics, Nonparametric
Reg. No./Substance:
0/Nitrates; 0/Nitrites; 10102-43-9/Nitric Oxide

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