| The nitric oxide donor ITF 1129 augments subendocardial blood flow during exercise-induced myocardial ischemia. | |
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MedLine Citation:
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PMID: 9300323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of the nitric oxide donor ITF 1129 and nitroglycerin (NTG) on myocardial blood flow was examined in dogs with a Doppler velocity probe, hydraulic occluder, and indwelling microcatheter in the left anterior descending coronary artery (LAD). Studies were performed during treadmill exercise in the presence of a coronary artery stenosis. The effects of ITF 1129 in doses of 3 and 10 micrograms/kg/min i.v. were compared with NTG (2 micrograms/kg/min i.v.). Neither ITF 1129 nor NTG caused significant alteration of heart rate, arterial blood pressure, or left ventricular systolic pressure. During partial inflation of the occluder to decrease distal coronary pressure to 55 +/- 2 mm Hg, mean myocardial blood flow measured with microspheres was 0.72 +/- 0.14 ml/min/g in the region perfused by the stenotic coronary artery compared with 2.93 +/- 0.40 ml/min/g in a normally perfused control region. With no change in distal coronary pressure, ITF 1129 increased mean myocardial blood flow in the stenosis perfused region to 1.15 +/- 0.24 ml/min/g (3 micrograms/kg/min i.v.) and to 1.20 +/- 0.28 ml/ min/g (10 micrograms/kg/min i.v.), whereas NTG (2 micrograms/kg/min iv) increased blood flow to 1.16 +/- 0.22 ml/min/g (each p < 0.05). The increase in myocardial blood flow produced by ITF 1129 or NTG occurred principally in the deeper myocardial layers with no change in subepicardial flow. As a result, the subendocardial/subepicardial blood flow ratio (ENDO/EPI) increased from 0.44 +/- 0.09 during control stenosis to 0.85 +/- 0.13 after ITF 1129 (10 micrograms/kg/min i.v.) and to 0.81 +/- 0.12 after NTG. Neither ITF 1129 nor NTG significantly altered myocardial blood flow in the normally perfused control region. The effect of ITF 1129 and NTG on myocardial perfusion occurred without alterations of distal coronary pressure or left ventricular diastolic pressure, indicating a primary effect on the intramural coronary microvasculature. |
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Authors:
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Y Ishibashi; J Mizrahi; D J Duncker; R J Bache |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 30 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1997 Sep |
Date Detail:
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Created Date: 1997-10-20 Completed Date: 1997-10-20 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 374-82 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Minnesota Medical School, Minneapolis, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Dogs Hemodynamics / drug effects Myocardial Contraction / drug effects* Myocardial Ischemia / drug therapy* Nitric Oxide / metabolism Nitroglycerin / pharmacology Regional Blood Flow / drug effects Vasodilator Agents / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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HL20598/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 55-63-0/Nitroglycerin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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